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Science 17 May 2002:
Vol. 296. no. 5571, pp. 1316 - 1319
DOI: 10.1126/science.1068310
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Reports

Heterotopic Shift of Epithelial-Mesenchymal Interactions in Vertebrate Jaw Evolution

Yasuyo Shigetani,1* Fumiaki Sugahara,2 Yayoi Kawakami,2 Yasunori Murakami,1 Shigeki Hirano,3 Shigeru Kuratani12dagger

Genes involved in late specification of the mandibular arch, the source of the vertebrate jaw, are expressed with similar patterns in the oral regions of chick and lamprey embryos. However, morphological comparisons indicate that apparently orthologous homeobox genes were expressed in different subdivisions of the ectomesenchyme in the two species. Therefore, the homology and gene expression of the oral region are uncoupled during the transition from agnathan to gnathostome; we conclude that a heterotopic shift of tissue interaction was involved in the evolution of the jaw.

1 Laboratory for Evolutionary Morphology, Center for Developmental Biology, RIKEN, Hyogo 650-0047, Japan.
2 Department of Biology, Okayama University, Okayama 700-8530, Japan.
3 Department of Medical Technology, Niigata University, Niigata 951-8518, Japan.
*   Present address: Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

dagger    To whom correspondence should be addressed. E-mail: saizo{at}cdb.riken.go.jp

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Science. ISSN 0036-8075 (print), 1095-9203 (online)