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Science 12 April 2002:
Vol. 296. no. 5566, pp. 273 - 275
DOI: 10.1126/science.1071208
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

IMMUNOLOGY:
Enhanced: Pathogen Surveillance--the Flies Have It

Ranjiv S. Khush, François Leulier, Bruno Lemaitre

Discoveries about the innate immune systems of flies and mammals reveal startling similarities between these two systems. In a Perspective, Khush et al., discuss new findings (Choe et al.) showing a key role for pattern recognition receptors of the peptidoglycan recognition protein family in the induction of appropriate immune responses in the fruit fly.

R. S. Khush is in the Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. F. Leulier and B. Lemaitre are at the Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette, France. E-mail: lemaitre{at}cgm.cnrs-gif.fr

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