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Science 5 April 2002:
Vol. 296. no. 5565, p. 9
DOI: 10.1126/science.296.5565.9m
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This Week in Science
Restricted accessibility of DNA through association with heterochromatin is an important mechanism for gene regulation. In budding yeast, repression of genes also occurs at the periphery of the nucleus, although it is not clear if a similar mechanism exists in higher eukaryotes. Using two- and three-dimensional fluorescence in situ hybridization (FISH), Kosak et al. (p. 158) observed that B cell immunoglobulin (Ig) genes preferentially associate with the nuclear periphery in non-B cells, but were centrally disposed in B cells. The idea that these distinct nuclear locations regulate Ig gene rearrangement and expression was supported by the observation that movement away from the nuclear periphery was limited in cells that had been denied signals known to activate Ig gene rearrangement. Furthermore, compaction of the large Ig heavy chain locus occurred when it was centrally positioned, consistent with the need for the close proximity of VH gene segments during V(D)J rearrangement.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
