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Science 22 March 2002:
Vol. 295. no. 5563, pp. 2255 - 2258
DOI: 10.1126/science.1068819
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Reports

Adaptive Immune Response of Vgamma 2V&dgr;2+ T Cells During Mycobacterial Infections

Yun Shen,12 Dejiang Zhou,12 Liyou Qiu,12 Xioamin Lai,12 Meredith Simon,3 Ling Shen,2 Zhongchen Kou,12 Qifan Wang,12 Liming Jiang,12 Jim Estep,4 Robert Hunt,4 Michelle Clagett,4 Prabhat K. Sehgal,3 Yunyaun Li,12 Xuejun Zeng,12 Craig T. Morita,5 Michael B. Brenner,6 Norman L. Letvin,2 Zheng W. Chen*12

To examine the role of T cell receptor (TCR) in gamma delta T cells in adaptive immunity, a macaque model was used to follow Vgamma 2Vdelta 2+ T cell responses to mycobacterial infections. These phosphoantigen-specific gamma delta T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vgamma 2Vdelta 2+ T cells were also seen during Mycobacterium tuberculosis infection of naïve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vgamma 2Vdelta 2+ T cells may contribute to adaptive immunity to mycobacterial infections.

1 Tuberculosis Research Unit,
2 Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
3 New England Regional Primate Research Center, Southboro, MA 01772, USA.
4 Battelle Medical Research and Evaluation Facility, Battelle Memorial Institute, Columbus, Ohio 43201, USA.
5 Division of Rheumatology, Department of Internal Medicine, and the Interdisciplinary Group on Immunology, University of Iowa, Iowa City, IA 52242, USA.
6 Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed. E-mail, zchen{at}caregroup.harvard.edu

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