Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 March 2002:
Vol. 295. no. 5563, pp. 2228 - 2229
DOI: 10.1126/science.1070766
Prev | Table of Contents | Next

Perspectives

SIGNAL TRANSDUCTION:
Hot and Cold TRP Ion Channels

David E. Clapham

Tasting menthol evokes a cool sensation. In his Perspective, Clapham discusses new work published elsewhere that identifies a TRP ion channel, which is opened by both cold temperature and menthol. The channel is expressed in neurons of the trigeminal and dorsal root ganglia that receive sensations from regions such as the mouth and in the skin.

The author is at the Howard Hughes Medical Institute, Cardiovascular Division, Children's Hospital, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. E-mail: dclapham{at}enders.tch.harvard.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Impaired Basal Thermal Homeostasis in Rats Lacking Capsaicin-sensitive Peripheral Small Sensory Neurons.
H. Yamashita, Z. Wang, Y. Wang, T. Furuyama, Y. Kontani, Y. Sato, and N. Mori (2008)
J. Biochem. 143, 385-393
   Abstract »    Full Text »    PDF »
Continuous Tonic Spike Activity in Spider Warm Cells in the Absence of Sensory Input.
E. Gingl and H. Tichy (2006)
J Neurophysiol 96, 989-997
   Abstract »    Full Text »    PDF »
Temperature Modulates Taste Responsiveness and Stimulates Gustatory Neurons in the Rat Geniculate Ganglion.
J. M. Breza, K. S. Curtis, and R. J. Contreras (2006)
J Neurophysiol 95, 674-685
   Abstract »    Full Text »    PDF »
The Channel Kinases TRPM6 and TRPM7 Are Functionally Nonredundant.
C. Schmitz, M. V. Dorovkov, X. Zhao, B. J. Davenport, A. G. Ryazanov, and A.-L. Perraud (2005)
J. Biol. Chem. 280, 37763-37771
   Abstract »    Full Text »    PDF »
Regulation of calcium signaling by polycystin-2.
H. F. Cantiello (2004)
Am J Physiol Renal Physiol 286, F1012-F1029
   Abstract »    Full Text »    PDF »
Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors.
G. Wasner, J. Schattschneider, A. Binder, and R. Baron (2004)
Brain 127, 1159-1171
   Abstract »    Full Text »    PDF »
Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond.
J.-B. Peng, E. M Brown, and M. A Hediger (2003)
J. Physiol. 551, 729-740
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)