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Science 22 February 2002:
Vol. 295. no. 5559, pp. 1479 - 1480
DOI: 10.1126/science.1069896
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Perspectives

IMMUNOLOGY:
The Immunological Synapse--a Multitasking System

P. Anton van der Merwe and Simon J. Davis

The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings (Lee et al.) demonstrating that T cell receptor signaling takes place well before formation of the immunological synapse, suggesting that this dynamic structure may have other functions.

P. A. van der Merwe is in the Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. E-mail: anton.vandermerwe@path.ox.ac.uk S. J. Davis is at the Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK. E-mail: sdavis{at}molbiol.ox.ac.uk

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