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SIGNAL TRANSDUCTION: Scaffolding Proteins--More Than Meets the Eye
Gary Johnson
The accepted pathway of MAPK activation is through a three kinase phosphorelay arrangement. However, as Johnson explains in his Perspective, new work has established an alternative way for a MAPK called p38a to be activated (Ge et al.). Apparently, a scaffolding protein called TAB1 that is devoid of any known catalytic activity is able to interact with p38a, inducing its autophosphorylation and consequent activation.
The author is in the Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. E-mail: gary.johnson{at}uchsc.edu
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