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Science 8 February 2002:
Vol. 295. no. 5557, p. 1003
DOI: 10.1126/science.295.5557.1003
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News

Not Blood Simple

Erik Stokstad

Compounds that act like blood to deliver oxygen are in the final stretch of clinical trials after decades of setbacks due to the complexity of hemoglobin and its sometimes surprising effects on humans when it's not ensconced in red blood cells. A handful of companies have persevered, however, predicting an ever greater need for blood substitutes as growing numbers of elderly patients needing blood-intensive surgery such as hip repairs or replacements strain the existing donor supply.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)