Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Carlos Lois,*Elizabeth J. Hong,*Shirley Pease,Eric J. Brown,David Baltimore
Single-cell mouse embryos were infected in vitro with recombinant
lentiviral vectors to generate transgenic mice carryingthe green
fluorescent protein (GFP) gene driven by a ubiquitouslyexpressing
promoter. Eighty percent of founder mice carried atleast
one copy of the transgene, and 90% of these expressed GFPat high
levels. Progeny inherited the transgene(s) and displayedgreen
fluorescence. Mice generated using lentiviral vectors withmuscle-specific and T lymphocyte-specific promoters expressedhigh levels of GFP only in the appropriate cell types. We havealso
generated transgenic rats that express GFP at high levels,suggesting
that this technique can be used to produce other transgenicanimal
species.
Division of Biology, California Institute of Technology, Pasadena,
CA 91125, USA.
*
These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail:
baltimo{at}caltech.edu
Stress-induced senescence exaggerates postinjury neointimal formation in the old vasculature.
S. J. Khan, S. Pham, Y. Wei, D. Mateo, M. St-Pierre, T. M. Fletcher, and R. I. Vazquez-Padron (2010)
Am J Physiol Heart Circ Physiol
298, H66-H74
|Abstract »|Full Text »|PDF »
Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3{beta}-Hydroxysterol {Delta}24-Reductase.
T. Nishimura, M. Kohara, K. Izumi, Y. Kasama, Y. Hirata, Y. Huang, M. Shuda, C. Mukaidani, T. Takano, Y. Tokunaga, et al. (2009)
J. Biol. Chem.
284, 36442-36452
|Abstract »|Full Text »|PDF »
HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells.
B. Dai, L. Yang, H. Yang, B. Hu, D. Baltimore, and P. Wang (2009)
PNAS
106, 20382-20387
|Abstract »|Full Text »|PDF »
Production of Germline Transgenic Prairie Voles (Microtus ochrogaster) Using Lentiviral Vectors.
Z. R. Donaldson, S.-H. Yang, A. W.S. Chan, and L. J. Young (2009)
Biol Reprod
81, 1189-1195
|Abstract »|Full Text »|PDF »
Analysis of the Role of Tripeptidyl Peptidase II in MHC Class I Antigen Presentation In Vivo.
M. Kawahara, I. A. York, A. Hearn, D. Farfan, and K. L. Rock (2009)
J. Immunol.
183, 6069-6077
|Abstract »|Full Text »|PDF »
The Tec Family Kinase Itk Exists as a Folded Monomer in Vivo.
A Noisy Paracrine Signal Determines the Cellular NF-{kappa}B Response to Lipopolysaccharide.
T. K. Lee, E. M. Denny, J. C. Sanghvi, J. E. Gaston, N. D. Maynard, J. J. Hughey, and M. W. Covert (2009)
Science Signaling
2, ra65
|Abstract »|Full Text »|PDF »
The Mre11 Complex and the Response to Dysfunctional Telomeres.
C. L. Attwooll, M. Akpinar, and J. H. J. Petrini (2009)
Mol. Cell. Biol.
29, 5540-5551
|Abstract »|Full Text »|PDF »
"Gene Targeting in the Rat? Cut it out!".
B. M. G. Smits and M. N. Gould (2009)
Mol. Interv.
9, 226-229
|Full Text »|PDF »
Clearance of Measles Virus from Persistently Infected Cells by Short Hairpin RNA.
M. Zinke, S. Kendl, K. Singethan, M. Fehrholz, D. Reuter, L. Rennick, M. J. Herold, and J. Schneider-Schaulies (2009)
J. Virol.
83, 9423-9431
|Abstract »|Full Text »|PDF »
Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.
S. I. Mayer, O. G. Rossler, T. Endo, P. Charnay, and G. Thiel (2009)
J. Cell Sci.
122, 3340-3350
|Abstract »|Full Text »|PDF »
The GTPase Rab3b/3c-positive recycling vesicles are involved in cross-presentation in dendritic cells.
L. Zou, J. Zhou, J. Zhang, J. Li, N. Liu, L. Chai, N. Li, T. Liu, L. Li, Z. Xie, et al. (2009)
PNAS
106, 15801-15806
|Abstract »|Full Text »|PDF »
Derivation of induced pluripotent stem cells from pig somatic cells.
T. Ezashi, B. P. V. L. Telugu, A. P. Alexenko, S. Sachdev, S. Sinha, and R. M. Roberts (2009)
PNAS
106, 10993-10998
|Abstract »|Full Text »|PDF »
PSD-95 Is Essential for Hallucinogen and Atypical Antipsychotic Drug Actions at Serotonin Receptors.
A. I. Abbas, P. N. Yadav, W.-D. Yao, M. I. Arbuckle, S. G. N. Grant, M. G. Caron, and B. L. Roth (2009)
J. Neurosci.
29, 7124-7136
|Abstract »|Full Text »|PDF »
Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function.
A. S. Lewis, E. Schwartz, C. Savio Chan, Y. Noam, M. Shin, W. J. Wadman, D. James Surmeier, T. Z. Baram, R. L. Macdonald, and D. M. Chetkovich (2009)
J. Neurosci.
29, 6250-6265
|Abstract »|Full Text »|PDF »
Cdc37 Regulates Ryk Signaling by Stabilizing the Cleaved Ryk Intracellular Domain.
J. Lyu, R. L. Wesselschmidt, and W. Lu (2009)
J. Biol. Chem.
284, 12940-12948
|Abstract »|Full Text »|PDF »
Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons.
M. Ishikawa, P. Mu, J. T. Moyer, J. A. Wolf, R. M. Quock, N. M. Davies, X.-t. Hu, O. M. Schluter, and Y. Dong (2009)
J. Neurosci.
29, 5820-5831
|Abstract »|Full Text »|PDF »
Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide.
Y. Sasaki, B. P. S. Vohra, F. E. Lund, and J. Milbrandt (2009)
J. Neurosci.
29, 5525-5535
|Abstract »|Full Text »|PDF »
Synaptic SAP97 Isoforms Regulate AMPA Receptor Dynamics and Access to Presynaptic Glutamate.
C. L. Waites, C. G. Specht, K. Hartel, S. Leal-Ortiz, D. Genoux, D. Li, R. C. Drisdel, O. Jeyifous, J. E. Cheyne, W. N. Green, et al. (2009)
J. Neurosci.
29, 4332-4345
|Abstract »|Full Text »|PDF »
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-{kappa}B/RelA.
X. Mao, N. Gluck, D. Li, G. N. Maine, H. Li, I. W. Zaidi, A. Repaka, M. W. Mayo, and E. Burstein (2009)
Genes & Dev.
23, 849-861
|Abstract »|Full Text »|PDF »
Epidermal Growth Factor Receptor and PTEN Modulate Tissue Factor Expression in Glioblastoma through JunD/Activator Protein-1 Transcriptional Activity.
Y. Rong, V. E. Belozerov, C. Tucker-Burden, G. Chen, D. L. Durden, J. J. Olson, E. G. Van Meir, N. Mackman, and D. J. Brat (2009)
Cancer Res.
69, 2540-2549
|Abstract »|Full Text »|PDF »
PSD-95 Uncouples Dopamine-Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex.
J. Zhang, T.-X. Xu, P. J. Hallett, M. Watanabe, S. G. N. Grant, O. Isacson, and W.-D. Yao (2009)
J. Neurosci.
29, 2948-2960
|Abstract »|Full Text »|PDF »
AMPA receptor and GEF-H1/Lfc complex regulates dendritic spine development through RhoA signaling cascade.
PTEN Loss Promotes Mitochondrially Dependent Type II Fas-Induced Apoptosis via PEA-15.
J. W. Peacock, J. Palmer, D. Fink, S. Ip, E. M. Pietras, A. L.-F. Mui, S. W. Chung, M. E. Gleave, M. E. Cox, R. Parsons, et al. (2009)
Mol. Cell. Biol.
29, 1222-1234
|Abstract »|Full Text »|PDF »
Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.
C. A. Fasano, T. N. Phoenix, E. Kokovay, N. Lowry, Y. Elkabetz, J. T. Dimos, I. R. Lemischka, L. Studer, and S. Temple (2009)
Genes & Dev.
23, 561-574
|Abstract »|Full Text »|PDF »
Imaging chemokine receptor dimerization with firefly luciferase complementation.
Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes..
X. M. Luo, E. Maarschalk, R. M. O'Connell, P. Wang, L. Yang, and D. Baltimore (2009)
Blood
113, 1422-1431
|Abstract »|Full Text »|PDF »
Rad50 Is Dispensable for the Maintenance and Viability of Postmitotic Tissues.
C. A. Adelman, S. De, and J. H. J. Petrini (2009)
Mol. Cell. Biol.
29, 483-492
|Abstract »|Full Text »|PDF »
Reprogramming of murine and human somatic cells using a single polycistronic vector.
B. W. Carey, S. Markoulaki, J. Hanna, K. Saha, Q. Gao, M. Mitalipova, and R. Jaenisch (2009)
PNAS
106, 157-162
|Abstract »|Full Text »|PDF »
Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis.
G. Chawla, C.-H. Lin, A. Han, L. Shiue, M. Ares Jr., and D. L. Black (2009)
Mol. Cell. Biol.
29, 201-213
|Abstract »|Full Text »|PDF »
Various Physical Stress Factors on Rat Sperm Motility, Integrity of Acrosome, and Plasma Membrane.
The origin of post-injury neointimal cells in the rat balloon injury model.
L. Rodriguez-Menocal, M. St-Pierre, Y. Wei, S. Khan, D. Mateu, M. Calfa, A. A. Rahnemai-Azar, G. Striker, S. M. Pham, and R. I. Vazquez-Padron (2009)
Cardiovasc Res
81, 46-53
|Abstract »|Full Text »|PDF »
{alpha}-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.
W.-H. Lien, V. I. Gelfand, and V. Vasioukhin (2008)
J. Cell Biol.
183, 989-997
|Abstract »|Full Text »|PDF »
The High-Mobility Group A1a/Signal Transducer and Activator of Transcription-3 Axis: An Achilles Heel for Hematopoietic Malignancies?.
J. Hillion, S. Dhara, T. F. Sumter, M. Mukherjee, F. Di Cello, A. Belton, J. Turkson, S. Jaganathan, L. Cheng, Z. Ye, et al. (2008)
Cancer Res.
68, 10121-10127
|Abstract »|Full Text »|PDF »
Expression of the Transcriptional Repressor ATF3 in Gonadotrophs Is Regulated by Egr-1, CREB, and ATF2 after Gonadotropin-Releasing Hormone Receptor Stimulation.
S. I. Mayer, V. Dexheimer, E. Nishida, S. Kitajima, and G. Thiel (2008)
Endocrinology
149, 6311-6325
|Abstract »|Full Text »|PDF »
Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression.
P. Goldhoff, N. M. Warrington, D. D. Limbrick Jr., A. Hope, B. M. Woerner, E. Jackson, A. Perry, D. Piwnica-Worms, and J. B. Rubin (2008)
Clin. Cancer Res.
14, 7717-7725
|Abstract »|Full Text »|PDF »
After Injection into the Striatum, in Vitro-Differentiated Microglia- and Bone Marrow-Derived Dendritic Cells Can Leave the Central Nervous System via the Blood Stream.
S. Hochmeister, M. Zeitelhofer, J. Bauer, E.-M. Nicolussi, M.-T. Fischer, B. Heinke, E. Selzer, H. Lassmann, and M. Bradl (2008)
Am. J. Pathol.
173, 1669-1681
|Abstract »|Full Text »|PDF »
Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats.
M. J. Herold, J. van den Brandt, J. Seibler, and H. M. Reichardt (2008)
PNAS
105, 18507-18512
|Abstract »|Full Text »|PDF »
Jakmip1 Is Expressed upon T Cell Differentiation and Has an Inhibitory Function in Cytotoxic T Lymphocytes.
V. Libri, D. Schulte, A. van Stijn, J. Ragimbeau, L. Rogge, and S. Pellegrini (2008)
J. Immunol.
181, 5847-5856
|Abstract »|Full Text »|PDF »
Sequential development of synapses in dendritic domains during adult neurogenesis.
Synapsin IIa Controls the Reserve Pool of Glutamatergic Synaptic Vesicles.
D. Gitler, Q. Cheng, P. Greengard, and G. J. Augustine (2008)
J. Neurosci.
28, 10835-10843
|Abstract »|Full Text »|PDF »
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis.
S. Leal-Ortiz, C. L. Waites, R. Terry-Lorenzo, P. Zamorano, E. D. Gundelfinger, and C. C. Garner (2008)
J. Cell Biol.
181, 831-846
|Abstract »|Full Text »|PDF »
Lentiviral-Mediated Transcriptional Targeting of Dendritic Cells for Induction of T Cell Tolerance In Vivo.
C. Dresch, S. L. Edelmann, P. Marconi, and T. Brocker (2008)
J. Immunol.
181, 4495-4506
|Abstract »|Full Text »|PDF »
A system for Cre-regulated RNA interference in vivo.
P. Stern, S. Astrof, S. J. Erkeland, J. Schustak, P. A. Sharp, and R. O. Hynes (2008)
PNAS
105, 13895-13900
|Abstract »|Full Text »|PDF »
The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF-{kappa}B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association.
Inhibition of Activated Fibroblast Growth Factor Receptor 2 in Endometrial Cancer Cells Induces Cell Death Despite PTEN Abrogation.
S. A. Byron, M. G. Gartside, C. L. Wellens, M. A. Mallon, J. B. Keenan, M. A. Powell, P. J. Goodfellow, and P. M. Pollock (2008)
Cancer Res.
68, 6902-6907
|Abstract »|Full Text »|PDF »
Method for Single-Cell Sorting and Expansion of Genetically Modified Human Embryonic Stem Cells.
C. R. Nicholas and R. A. Reijo Pera (2008)
CSH Protocols
2008, pdb.prot5045
|Abstract »|Full Text »
NFX1 Interacts with mSin3A/Histone Deacetylase To Repress hTERT Transcription in Keratinocytes.
M. Xu, W. Luo, D. J. Elzi, C. Grandori, and D. A. Galloway (2008)
Mol. Cell. Biol.
28, 4819-4828
|Abstract »|Full Text »|PDF »
Constitutively Active Protein Kinase A Qualitatively Mimics the Effects of Follicle-Stimulating Hormone on Granulosa Cell Differentiation.
R. Escamilla-Hernandez, L. Little-Ihrig, K. E. Orwig, J. Yue, U. Chandran, and A. J. Zeleznik (2008)
Mol. Endocrinol.
22, 1842-1852
|Abstract »|Full Text »|PDF »
Encoding NF-{kappa}B temporal control in response to TNF: distinct roles for the negative regulators I{kappa}B{alpha} and A20.
S. L. Werner, J. D. Kearns, V. Zadorozhnaya, C. Lynch, E. O'Dea, M. P. Boldin, A. Ma, D. Baltimore, and A. Hoffmann (2008)
Genes & Dev.
22, 2093-2101
|Abstract »|Full Text »|PDF »
A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.
L. Berghella, L. De Angelis, T. De Buysscher, A. Mortazavi, S. Biressi, S. V. Forcales, D. Sirabella, G. Cossu, and B. J. Wold (2008)
Genes & Dev.
22, 2125-2138
|Abstract »|Full Text »|PDF »
Genotypic Features of Lentivirus Transgenic Mice.
M.-O. Sauvain, A. P. Dorr, B. Stevenson, A. Quazzola, F. Naef, M. Wiznerowicz, F. Schutz, V. Jongeneel, D. Duboule, F. Spitz, et al. (2008)
J. Virol.
82, 7111-7119
|Abstract »|Full Text »|PDF »
CD4+CD25- T Cells Transduced to Express MHC Class I-Restricted Epitope-Specific TCR Synthesize Th1 Cytokines and Exhibit MHC Class I-Restricted Cytolytic Effector Function in a Human Melanoma Model.
A. Chhabra, L. Yang, P. Wang, B. Comin-Anduix, R. Das, N. G. Chakraborty, S. Ray, S. Mehrotra, H. Yang, C. L. Hardee, et al. (2008)
J. Immunol.
181, 1063-1070
|Abstract »|Full Text »|PDF »
Critical Period Plasticity of Axonal Arbors of Layer 2/3 Pyramidal Neurons in Rat Somatosensory Cortex: Layer-Specific Reduction of Projections into Deprived Cortical Columns.
P. Broser, V. Grinevich, P. Osten, B. Sakmann, and D. J. Wallace (2008)
Cereb Cortex
18, 1588-1603
|Abstract »|Full Text »|PDF »
Generation of transgenic quail through germ cell-mediated germline transmission.
S. S. Shin, T. M. Kim, S. Y. Kim, T. W. Kim, H. W. Seo, S. K. Lee, S. C. Kwon, G. S. Lee, H. Kim, J. M. Lim, et al. (2008)
FASEB J
22, 2435-2444
|Abstract »|Full Text »|PDF »
Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo.
B. Zhou, D. K. Ann, P. Flodby, P. Minoo, J. M. Liebler, E. D. Crandall, and Z. Borok (2008)
Am J Physiol Cell Physiol
295, C111-C120
|Abstract »|Full Text »|PDF »
Silencing of the Mineralocorticoid Receptor by Ribonucleic Acid Interference in Transgenic Rats Disrupts Endocrine Homeostasis.
H.-Y. Lim, J. van den Brandt, M. Fassnacht, B. Allolio, M. J. Herold, and H. M. Reichardt (2008)
Mol. Endocrinol.
22, 1304-1311
|Abstract »|Full Text »|PDF »
GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation.
Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth.
J. Zheng, W.-H. Shen, T.-J. Lu, Y. Zhou, Q. Chen, Z. Wang, T. Xiang, Y.-C. Zhu, C. Zhang, S. Duan, et al. (2008)
J. Biol. Chem.
283, 13280-13288
|Abstract »|Full Text »|PDF »
Bimodal Viral Vectors and In Vivo Imaging Reveal the Fate of Human Neural Stem Cells in Experimental Glioma Model.
K. Shah, S. Hingtgen, R. Kasmieh, J. L. Figueiredo, E. Garcia-Garcia, A. Martinez-Serrano, X. Breakefield, and R. Weissleder (2008)
J. Neurosci.
28, 4406-4413
|Abstract »|Full Text »|PDF »
From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
C. Kim, S. Wilcox-Adelman, Y. Sano, W.-J. Tang, R. J. Collier, and J. M. Park (2008)
PNAS
105, 6150-6155
|Abstract »|Full Text »|PDF »
Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo.
J. K. Alder, R. W. Georgantas III, R. L. Hildreth, I. M. Kaplan, S. Morisot, X. Yu, M. McDevitt, and C. I. Civin (2008)
J. Immunol.
180, 5645-5652
|Abstract »|Full Text »|PDF »
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
M. Wernig, J.-P. Zhao, J. Pruszak, E. Hedlund, D. Fu, F. Soldner, V. Broccoli, M. Constantine-Paton, O. Isacson, and R. Jaenisch (2008)
PNAS
105, 5856-5861
|Abstract »|Full Text »|PDF »
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
F. Dayyani, J. Wang, J.-R. J. Yeh, E.-Y. Ahn, E. Tobey, D.-E. Zhang, I. D. Bernstein, R. T. Peterson, and D. A. Sweetser (2008)
Blood
111, 4338-4347
|Abstract »|Full Text »|PDF »
Telencephalic Neurons Monosynaptically Link Brainstem and Forebrain Premotor Networks Necessary for Song.
T. F. Roberts, M. E. Klein, M. F. Kubke, J. M. Wild, and R. Mooney (2008)
J. Neurosci.
28, 3479-3489
|Abstract »|Full Text »|PDF »
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain.
A. Buffo, I. Rite, P. Tripathi, A. Lepier, D. Colak, A.-P. Horn, T. Mori, and M. Gotz (2008)
PNAS
105, 3581-3586
|Abstract »|Full Text »|PDF »
A novel transgenic mouse model produced from lentiviral germline integration for the study of {beta}-thalassemia gene therapy.
W. Li, S. Xie, X. Guo, X. Gong, S. Wang, D. Lin, J. Zhang, Z. Ren, S. Huang, F. Zeng, et al. (2008)
Haematologica
93, 356-362
|Abstract »|Full Text »|PDF »
Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells.
K. Mizuta, G. Gallos, D. Zhu, F. Mizuta, F. Goubaeva, D. Xu, R. A. Panettieri Jr., J. Yang, and C. W. Emala Sr. (2008)
Am J Physiol Lung Cell Mol Physiol
294, L523-L534
|Abstract »|Full Text »|PDF »
Adeno-associated virus (AAV)-mediated transduction of male germ line stem cells results in transgene transmission after germ cell transplantation.
A. Honaramooz, S. Megee, W. Zeng, M. M. Destrempes, S. A. Overton, J. Luo, H. Galantino-Homer, M. Modelski, F. Chen, S. Blash, et al. (2008)
FASEB J
22, 374-382
|Abstract »|Full Text »|PDF »
JAM-A is both essential and inhibitory to development of hepatic polarity in WIF-B cells.
L. T. Braiterman, S. Heffernan, L. Nyasae, D. Johns, A. P. See, R. Yutzy, A. McNickle, M. Herman, A. Sharma, U. P. Naik, et al. (2008)
Am J Physiol Gastrointest Liver Physiol
294, G576-G588
|Abstract »|Full Text »|PDF »
Lentiviral (HIV)-based RNA interference screen in human B-cell receptor regulatory networks reveals MCL1-induced oncogenic pathways.
A. Ruiz-Vela, M. Aggarwal, P. de la Cueva, C. Treda, B. Herreros, D. Martin-Perez, O. Dominguez, and M. A. Piris (2008)
Blood
111, 1665-1676
|Abstract »|Full Text »|PDF »
Siah Proteins Induce the Epidermal Growth Factor-dependent Degradation of Phospholipase C{epsilon}.
S. Yun, A. Moller, S.-K. Chae, W.-P. Hong, Y. J. Bae, D. D. L. Bowtell, S. H. Ryu, and P.-G. Suh (2008)
J. Biol. Chem.
283, 1034-1042
|Abstract »|Full Text »|PDF »
Retinal progenitor cells can produce restricted subsets of horizontal cells.
Mint3/X11{gamma} Is an ADP-Ribosylation Factor-dependent Adaptor that Regulates the Traffic of the Alzheimer's Precursor Protein from the Trans-Golgi Network.
P. Shrivastava-Ranjan, V. Faundez, G. Fang, H. Rees, J. J. Lah, A. I. Levey, and R. A. Kahn (2008)
Mol. Biol. Cell
19, 51-64
|Abstract »|Full Text »|PDF »
Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.
J. McLaughlin, D. Cheng, O. Singer, R. U. Lukacs, C. G. Radu, I. M. Verma, and O. N. Witte (2007)
PNAS
104, 20501-20506
|Abstract »|Full Text »|PDF »
Induction of Apoptosis in Plasma Cells by B Lymphocyte Induced Maturation Protein-1 Knockdown.
F.-R. Lin, H.-K. Kuo, H.-Y. Ying, F.-H. Yang, and K.-I Lin (2007)
Cancer Res.
67, 11914-11923
|Abstract »|Full Text »|PDF »
The Kruppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis.
M. Wiznerowicz, J. Jakobsson, J. Szulc, S. Liao, A. Quazzola, F. Beermann, P. Aebischer, and D. Trono (2007)
J. Biol. Chem.
282, 34535-34541
|Abstract »|Full Text »|PDF »
Restoration of the balanced {alpha}/{beta}-globin gene expression in {beta}654-thalassemia mice using combined RNAi and antisense RNA approach.
S.-Y. Xie, Z.-R. Ren, J.-Z. Zhang, X.-B. Guo, Q.-X. Wang, S. Wang, D. Lin, X.-L. Gong, W. Li, S.-Z. Huang, et al. (2007)
Hum. Mol. Genet.
16, 2616-2625
|Abstract »|Full Text »|PDF »
Lentiviral vectors: are they the future of animal transgenesis?.
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
Z. Miao, K. E. Luker, B. C. Summers, R. Berahovich, M. S. Bhojani, A. Rehemtulla, C. G. Kleer, J. J. Essner, A. Nasevicius, G. D. Luker, et al. (2007)
PNAS
104, 15735-15740
|Abstract »|Full Text »|PDF »
Development of Transgenic Chickens Expressing Human Parathormone Under the Control of a Ubiquitous Promoter by Using a Retrovirus Vector System.
S. H. Lee, M. K. Gupta, D. W. Han, S. Y. Han, S. J. Uhm, T. Kim, and H. T. Lee (2007)
Poult. Sci.
86, 2221-2227
|Abstract »|Full Text »|PDF »
SAP97 Directs the Localization of Kv4.2 to Spines in Hippocampal Neurons: REGULATION BY CaMKII.
F. Gardoni, D. Mauceri, E. Marcello, C. Sala, M. Di Luca, and A. Jeromin (2007)
J. Biol. Chem.
282, 28691-28699
|Abstract »|Full Text »|PDF »
Epidermal terminal differentiation depends on B lymphocyte-induced maturation protein-1.
E. Magnusdottir, S. Kalachikov, K. Mizukoshi, D. Savitsky, A. Ishida-Yamamoto, A. A. Panteleyev, and K. Calame (2007)
PNAS
104, 14988-14993
|Abstract »|Full Text »|PDF »
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
P. Maurel, S. Einheber, J. Galinska, P. Thaker, I. Lam, M. B. Rubin, S. S. Scherer, Y. Murakami, D. H. Gutmann, and J. L. Salzer (2007)
J. Cell Biol.
178, 861-874
|Abstract »|Full Text »|PDF »
Regulation of Neurite Growth by Spontaneous Ca2+ Oscillations in Astrocytes.
K. Kanemaru, Y. Okubo, K. Hirose, and M. Iino (2007)
J. Neurosci.
27, 8957-8966
|Abstract »|Full Text »|PDF »
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.
P. Soulas-Sprauel, G. Le Guyader, P. Rivera-Munoz, V. Abramowski, C. Olivier-Martin, C. Goujet-Zalc, P. Charneau, and J.-P. de Villartay (2007)
J. Exp. Med.
204, 1717-1727
|Abstract »|Full Text »|PDF »
Efficient transgenic rat production by a lentiviral vector.
M. Michalkiewicz, T. Michalkiewicz, A. M. Geurts, R. J. Roman, G. R. Slocum, O. Singer, D. Weihrauch, A. S. Greene, M. Kaldunski, I. M. Verma, et al. (2007)
Am J Physiol Heart Circ Physiol
293, H881-H894
|Abstract »|Full Text »|PDF »
Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms.
Y. Dzhashiashvili, Y. Zhang, J. Galinska, I. Lam, M. Grumet, and J. L. Salzer (2007)
J. Cell Biol.
177, 857-870
|Abstract »|Full Text »|PDF »
Conditional ablation of GFR{alpha}1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype.
T. Uesaka, S. Jain, S. Yonemura, Y. Uchiyama, J. Milbrandt, and H. Enomoto (2007)
Development
134, 2171-2181
|Abstract »|Full Text »|PDF »
Soluble Ig-Like Transcript 3 Inhibits Tumor Allograft Rejection in Humanized SCID Mice and T Cell Responses in Cancer Patients.
N. Suciu-Foca, N. Feirt, Q.-Y. Zhang, G. Vlad, Z. Liu, H. Lin, C.-C. Chang, E. K. Ho, A. I. Colovai, H. Kaufman, et al. (2007)
J. Immunol.
178, 7432-7441
|Abstract »|Full Text »|PDF »
Control of Early Events in Olfactory Processing by Adult Neurogenesis.
Direct Intramyocardial But Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model.
S. Fukushima, A. Varela-Carver, S. R. Coppen, K. Yamahara, L. E. Felkin, J. Lee, P. J.R. Barton, C. M.N. Terracciano, M. H. Yacoub, and K. Suzuki (2007)
Circulation
115, 2254-2261
|Abstract »|Full Text »|PDF »
