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Science 1 February 2002:
Vol. 295. no. 5556, pp. 809 - 810
DOI: 10.1126/science.1069544
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Perspectives

NEUROBIOLOGY:
Chaperones Take Flight

Stephen L. Helfand

The fruit fly is turning out to be a valuable model of human neurodegenerative diseases such as Parkinson's disease (PD) and a useful tool for screening potential therapeutics for treating these illnesses. In his Perspective, Helfand discusses a new fly model of PD in which the loss of dopaminergic neurons is prevented by expression of chaperone proteins (Auluck et al.).

The author is in the Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. E-mail: shelfand{at}neuron.uchc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Torsin-Mediated Protection from Cellular Stress in the Dopaminergic Neurons of Caenorhabditis elegans.
S. Cao, C. C. Gelwix, K. A. Caldwell, and G. A. Caldwell (2005)
J. Neurosci. 25, 3801-3812
   Abstract »    Full Text »    PDF »
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.
P. K. Auluck, M. C. Meulener, and N. M. Bonini (2005)
J. Biol. Chem. 280, 2873-2878
   Abstract »    Full Text »    PDF »
Dysregulation of Stathmin, a Microtubule-Destabilizing Protein, and Up-Regulation of Hsp25, Hsp27, and the Antioxidant Peroxiredoxin 6 in a Mouse Model of Familial Amyotrophic Lateral Sclerosis.
C. W. Strey, D. Spellman, A. Stieber, J. O. Gonatas, X. Wang, J. D. Lambris, and N. K. Gonatas (2004)
Am. J. Pathol. 165, 1701-1718
   Abstract »    Full Text »    PDF »
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.
J. C. Greene, A. J. Whitworth, I. Kuo, L. A. Andrews, M. B. Feany, and L. J. Pallanck (2003)
PNAS 100, 4078-4083
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)