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Science 4 January 2002:
Vol. 295. no. 5552, pp. 134 - 137
DOI: 10.1126/science.1064521
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Reports

Nucleotide Variation Along the Drosophila melanogaster Fourth Chromosome

Wen Wang,1 Kevin Thornton,2 Andrew Berry,3 Manyuan Long12*

The Drosophila melanogaster fourth chromosome, believed to be nonrecombining and invariable, is a classic example of the effect of natural selection in eliminating genetic variation in linked loci. However, in a chromosome-wide assay of nucleotide variation in natural populations, we have observed a high level of polymorphism in a ~200-kilobase region and marked levels of polymorphism in several other fragments interspersed with regions of little variation, suggesting different evolutionary histories in different chromosomal domains. Statistical tests of neutral evolution showed that a few haplotypes predominate in the 200-kilobase polymorphic region. Finally, contrary to the expectation of no recombination, we identified six recombination events within the chromosome. Thus, positive Darwinian selection and recombination have affected the evolution of this chromosome.

1 Department of Ecology and Evolution,
2 Committee on Genetics, University of Chicago, 1101 East 57 Street, Chicago, IL 60637, USA.
3 Museum of Comparative Zoology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA.
*   To whom correspondence should be addressed. E-mail: mlong{at}midway.uchicago.edu

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