Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 December 2001:
Vol. 294. no. 5551, pp. 2497 - 2498
DOI: 10.1126/science.1067622
Prev | Table of Contents | Next

Perspectives

TRANSCRIPTION:
Switching Partners in a Regulatory Tango

Kenichi Nishioka and Danny Reinberg

The coactivator CBP/p300 cooperates with the enzyme CARM1 to boost the activity of the nuclear hormone receptor transcription factors. But what is the relationship between CBP/p300 and CARM1? As Nishioka and Reinberg explain in their Perspective, new work reveals that CARM1 regulates the availability of CBP/p300 by methylating the KIX domain of this coactivator.

The authors are at the Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA. E-mail: reinbedf{at}umdnj.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
EBNA3C Coactivation with EBNA2 Requires a SUMO Homology Domain.
A. Rosendorff, D. Illanes, G. David, J. Lin, E. Kieff, and E. Johannsen (2004)
J. Virol. 78, 367-377
   Abstract »    Full Text »    PDF »
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-{kappa}B or Activator Protein-1: Molecular Mechanisms for Gene Repression.
K. De Bosscher, W. Vanden Berghe, and G. Haegeman (2003)
Endocr. Rev. 24, 488-522
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)