Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Invitrogen

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 December 2001:
Vol. 294. no. 5551, pp. 2489 - 2490
DOI: 10.1126/science.1067916
Prev | Table of Contents | Next

Perspectives

ENZYMOLOGY:
Coenzymes and Radicals

Perry A. Frey

Organic radicals play an important role in many enzymatic reactions, but as Frey explains in his Perspective, information about their structure is hard to come by. He highlights the report by Chabrière et al., who have crystallized the enzyme pyruvate:ferredoxin oxidoreductase with the intermediate radical form of hydroxyethylidene-thiamine pyrophosphate bound to its active site. The structure of the radical provides important clues to its electronic structure.

The author is in the Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53705, USA. E-mail: frey{at}biochem.wisc.edu

Read the Full Text

ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)