Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 December 2001:
Vol. 294. no. 5550, pp. 2304 - 2305
DOI: 10.1126/science.1067546
Prev | Table of Contents | Next

Perspectives

BIOINFORMATICS:
Reality Simulation--Observe While It Happens

Herman J. C. Berendsen

Decades of method development and increasing computational power are enabling researchers to simulate complex biological processes in real time. In his Perspective, Berendsen highlights the report by de Groot and Grubmüller, who simulate the permeation of water through the membrane-channel protein aquaporin-1 at atomic resolution. Simulations of this sort provide insights into the permeation mechanism and can help to refine rate theories and to check the validity of approximations made to study events on much longer time scales.

The author is emeritus professor at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Nijenborgh 4, 9747 AG Groningen, Netherlands. E-mail: berendsen{at}chem.rug.nl

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conformational Transitions Induced by the Binding of MgATP to the Vitamin B12 ATP-binding Cassette (ABC) Transporter BtuCD.
E. O. Oloo and D. P. Tieleman (2004)
J. Biol. Chem. 279, 45013-45019
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)