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Science 30 November 2001:
Vol. 294. no. 5548, pp. 1842 - 1843
DOI: 10.1126/science.1067545
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Perspectives

NATURAL PRODUCT SYNTHESIS:
The Art of Total Synthesis

István E. Markó

Advances in synthetic strategies and analytical technology are allowing ever more natural product molecules to be synthesized. In his Perspective, Markó briefly reviews the history of this field and highlights the synthesis of ciguatoxin by Hirama et al. This marine toxin belongs to the ciguatera family of neurotoxins, which poison some 20,000 people every year. The elegant and highly convergent strategy developed by the authors will be helpful in the development of antibodies to ciguatoxin for the detection of contaminated seafood.

The author is at the Université Catholique de Louvain, Unité de Chimie Organique et Médicinale, Batîment Lavoisier, Place Louis Pasteur 1, B-1348 louvain-la-Neuve, Belgium. E-mail: marko{at}chim.ucl.ac.be

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Science. ISSN 0036-8075 (print), 1095-9203 (online)