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Science 23 November 2001:
Vol. 294. no. 5547, pp. 1661 - 1663
DOI: 10.1126/science.1066919
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Perspectives

CELL BIOLOGY:
Encounters in Space

Benjamin Geiger

Cultured cells are known to form focal and fibrillar adhesions with the substrate on which they grow. But to what extent these adhesions represent those formed in vivo is a matter of debate. In a Perspective, Geiger discusses new findings (Cukierman et al.) claiming that the formation of physiological adhesions depends on the correct combination of molecular composition, topography, and pliability of the matrix.

The author is in the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: benny.geiger{at}weizmann.ac.il

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