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CNS Synaptogenesis Promoted by Glia-Derived Cholesterol
Daniela H. Mauch,1Karl Nägler,13Stefan Schumacher,4Christian Göritz,13Eva-Christina Müller,2Albrecht Otto,2Frank W. Pfrieger13*
The molecular mechanisms controlling synaptogenesis in the central
nervous system (CNS) are poorly understood. Previous reportsshowed
that a glia-derived factor strongly promotes synapse developmentin
cultures of purified CNS neurons. Here, we identify this factoras
cholesterol complexed to apolipoprotein E-containing
lipoproteins.CNS neurons produce enough cholesterol to survive and
grow, butthe formation of numerous mature synapses demands additional
amountsthat must be provided by glia. Thus, the availability of
cholesterolappears to limit synapse development. This may explain the
delayedonset of CNS synaptogenesis after glia differentiation and
neurobehavioralmanifestations of defects in cholesterol or lipoprotein
homeostasis.
1 Synapse Group and
2 Protein Chemistry Group, Max-Delbrück-Center
for Molecular Medicine, D-13092 Berlin, Germany.
3 Max-Planck/CNRS Group, UPR 2396, Centre de
Neurochimie, F-67084 Strasbourg, France.
4 Institute
for Cell Biochemistry and Clinical Neurobiology, University of Hamburg,
D-20246 Hamburg, Germany.
*
To whom correspondence should be addressed. E-mail:
fw-pfrieger{at}gmx.de
The editors suggest the following Related Resources on Science sites:
In Science Magazine
LETTERS
Alexei R. Koudinov and Natalia V. Koudinova (22 March 2002) Science295 (5563), 2213a.
[DOI: 10.1126/science.295.5563.2213a] |Full Text »
PERSPECTIVES
Ben A. Barres and Stephen J. Smith (9 November 2001) Science294 (5545), 1296.
[DOI: 10.1126/science.1066724] |Summary »|Full Text »|PDF »
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|Abstract »|PDF »
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J. Biol. Chem.
279, 48654-48662
|Abstract »|Full Text »|PDF »
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161, 2123-2126
|Abstract »|Full Text »|PDF »
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279, 38770-38778
|Abstract »|Full Text »|PDF »
Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome.
M Witsch-Baumgartner, M Gruber, H G Kraft, M Rossi, P Clayton, M Giros, D Haas, R I Kelley, M Krajewska-Walasek, and G Utermann (2004)
J. Med. Genet.
41, 577-584
|Abstract »|Full Text »|PDF »
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I. Bjorkhem and S. Meaney (2004)
Arterioscler. Thromb. Vasc. Biol.
24, 806-815
|Abstract »|Full Text »
Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures.
H. Hayashi, R. B. Campenot, D. E. Vance, and J. E. Vance (2004)
J. Biol. Chem.
279, 14009-14015
|Abstract »|Full Text »|PDF »
A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.
P. C. Reid, N. Sakashita, S. Sugii, Y. Ohno-Iwashita, Y. Shimada, W. F. Hickey, and T.-Y. Chang (2004)
J. Lipid Res.
45, 582-591
|Abstract »|Full Text »|PDF »
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Y. Yang, W. Ge, Y. Chen, Z. Zhang, W. Shen, C. Wu, M. Poo, and S. Duan (2003)
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100, 15194-15199
|Abstract »|Full Text »|PDF »
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P. M. Greenwood and R. Parasuraman (2003)
Behav Cogn Neurosci Rev
2, 278-306
|Abstract »|PDF »
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B. Li, Z. Yang, J. Hou, A. McCracken, M. A. Jennings, and M. Y. J. Ma (2003)
Mol. Endocrinol.
17, 2365-2376
|Abstract »|Full Text »|PDF »
Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts.
C. Eroglu, B. Brugger, F. Wieland, and I. Sinning (2003)
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100, 10219-10224
|Abstract »|Full Text »|PDF »
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C. Xie, E. G. Lund, S. D. Turley, D. W. Russell, and J. M. Dietschy (2003)
J. Lipid Res.
44, 1780-1789
|Abstract »|Full Text »|PDF »
Long term neuropsychological outcome after head injury: relation to APOE genotype.
K Millar, J A R Nicoll, S Thornhill, G D Murray, and G M Teasdale (2003)
J. Neurol. Neurosurg. Psychiatry
74, 1047-1052
|Abstract »|Full Text »|PDF »
Cholesterol: from heart attacks to Alzheimer's disease.
Apolipoprotein E genotypes and clinical outcome in Guillain-Barre syndrome.
J Pritchard, R A C Hughes, J H Rees, H J Willison, and J A R Nicoll (2003)
J. Neurol. Neurosurg. Psychiatry
74, 971-973
|Abstract »|Full Text »|PDF »
Differential Effects of Neurotrophins and Schwann Cell-Derived Signals on Neuronal Survival/Growth and Synaptogenesis.
H. B. Peng, J.-F. Yang, Z. Dai, C. W. Lee, H. W. Hung, Z. H. Feng, and C.-P. Ko (2003)
J. Neurosci.
23, 5050-5060
|Abstract »|Full Text »|PDF »
Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover.
E. G. Lund, C. Xie, T. Kotti, S. D. Turley, J. M. Dietschy, and D. W. Russell (2003)
J. Biol. Chem.
278, 22980-22988
|Abstract »|Full Text »|PDF »
Genetic vulnerability following traumatic brain injury: the role of apolipoprotein E.
N Nathoo, R Chetty, J R van Dellen, and G H Barnett (2003)
Mol. Pathol.
56, 132-136
|Abstract »|Full Text »|PDF »
Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease.
S. Vuletic, L.-W. Jin, S. M. Marcovina, E. R. Peskind, T. Moller, and J. J. Albers (2003)
J. Lipid Res.
44, 1113-1123
|Abstract »|Full Text »|PDF »
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Y.-B. Liu, C.-C. Wu, L.-S. Lu, M.-J. Su, C.-W. Lin, S.-F. Lin, L. S. Chen, M. C. Fishbein, P.-S. Chen, and Y.-T. Lee (2003)
Circ. Res.
92, 1145-1152
|Abstract »|Full Text »|PDF »
L. Puglielli, B. C. Ellis, A. J. Saunders, and D. M. Kovacs (2003)
J. Biol. Chem.
278, 19777-19783
|Abstract »|Full Text »|PDF »
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J. Biol. Chem.
278, 18597-18605
|Abstract »|Full Text »|PDF »
Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.
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R. P. Koldamova, I. M. Lefterov, M. D. Ikonomovic, J. Skoko, P. I. Lefterov, B. A. Isanski, S. T. DeKosky, and J. S. Lazo (2003)
J. Biol. Chem.
278, 13244-13256
|Abstract »|Full Text »|PDF »
Lipoprotein Lipase Affects the Survival and Differentiation of Neural Cells Exposed to Very Low Density Lipoprotein.
E. Paradis, S. Clement, P. Julien, and M. R. Ven Murthy (2003)
J. Biol. Chem.
278, 9698-9705
|Abstract »|Full Text »|PDF »
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A. Kay, A. Petzold, M. Kerr, G. Keir, E. Thompson, and J. Nicoll (2003)
Stroke
34, 637-642
|Abstract »|Full Text »|PDF »
Apolipoprotein E {epsilon}4 allele, AD pathology, and the clinical expression of Alzheimer's disease.
D.A. Bennett, R.S. Wilson, J.A. Schneider, D.A. Evans, N.T. Aggarwal, S.E. Arnold, E.J. Cochran, E. Berry-Kravis, and J.L. Bienias (2003)
Neurology
60, 246-252
|Abstract »|Full Text »|PDF »
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M. Buttini, G.-Q. Yu, K. Shockley, Y. Huang, B. Jones, E. Masliah, M. Mallory, T. Yeo, F. M. Longo, and L. Mucke (2002)
J. Neurosci.
22, 10539-10548
|Abstract »|Full Text »|PDF »
Liver X receptors in the central nervous system: From lipid homeostasis to neuronal degeneration.
L. Wang, G. U. Schuster, K. Hultenby, Q. Zhang, S. Andersson, and J.-A. Gustafsson (2002)
PNAS
99, 13878-13883
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Statins as immunomodulators: Comparison with interferon-{beta}1b in MS.
O. Neuhaus, S. Strasser-Fuchs, F. Fazekas, B.C. Kieseier, G. Niederwieser, H.P. Hartung, and J.J. Archelos (2002)
Neurology
59, 990-997
|Abstract »|Full Text »|PDF »
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A. S. Pappu, R. D. Steiner, S. L. Connor, D. P. Flavell, D. S. Lin, L. Hatcher, D. R. Illingworth, and W. E. Connor (2002)
J. Lipid Res.
43, 1661-1669
|Abstract »|Full Text »|PDF »
