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Science 9 November 2001:
Vol. 294. no. 5545, pp. 1299 - 1304
DOI: 10.1126/science.1062023
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Review

The Guanine Nucleotide-Binding Switch in Three Dimensions

Ingrid R. Vetter, Alfred Wittinghofer

Guanine nucleotide-binding proteins regulate a variety of processes, including sensual perception, protein synthesis, various transport processes, and cell growth and differentiation. They act as molecular switches and timers that cycle between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states. Recent structural studies show that the switch apparatus itself is a conserved fundamental module but that its regulators and effectors are quite diverse in their structures and modes of interaction. Here we will try to define some underlying principles.

Max-Planck-Institut für Molekulare Physiologie, 44227 Dortmund, Germany.

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J. Biol. Chem. 279, 53419-53426
   Abstract »    Full Text »    PDF »
AGAP1, a Novel Binding Partner of Nitric Oxide-sensitive Guanylyl Cyclase.
S. Meurer, S. Pioch, K. Wagner, W. Muller-Esterl, and S. Gross (2004)
J. Biol. Chem. 279, 49346-49354
   Abstract »    Full Text »    PDF »
Conformational Changes in Human Arf1 on Nucleotide Exchange and Deletion of Membrane-binding Elements.
R. D. Seidel III, J. C. Amor, R. A. Kahn, and J. H. Prestegard (2004)
J. Biol. Chem. 279, 48307-48318
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Fourier Transform Infrared Spectroscopy on the Rap{middle dot}RapGAP Reaction, GTPase Activation without an Arginine Finger.
P. P. Chakrabarti, Y. Suveyzdis, A. Wittinghofer, and K. Gerwert (2004)
J. Biol. Chem. 279, 46226-46233
   Abstract »    Full Text »    PDF »
Human RAS Superfamily Proteins and Related GTPases.
J. Colicelli (2004)
Sci. STKE 2004, re13
   Abstract »    Full Text »    PDF »
Homo-oligomerization of ALS2 through Its Unique Carboxyl-terminal Regions Is Essential for the ALS2-associated Rab5 Guanine Nucleotide Exchange Activity and Its Regulatory Function on Endosome Trafficking.
R. Kunita, A. Otomo, H. Mizumura, K. Suzuki, J. Showguchi-Miyata, Y. Yanagisawa, S. Hadano, and J.-E Ikeda (2004)
J. Biol. Chem. 279, 38626-38635
   Abstract »    Full Text »    PDF »
Down-Regulation of Metallothionein, a Reactive Oxygen Scavenger, by the Small GTPase OsRac1 in Rice.
H. L. Wong, T. Sakamoto, T. Kawasaki, K. Umemura, and K. Shimamoto (2004)
Plant Physiology 135, 1447-1456
   Abstract »    Full Text »    PDF »


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