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Science 2 November 2001:
Vol. 294. no. 5544, pp. 1016 - 1017
DOI: 10.1126/science.1066729
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Perspectives

VIROLOGY:
HIV--Breaking the Rules for Nuclear Entry

Miriam Segura-Totten and Katherine L. Wilson

How does human immunodeficiency virus (HIV) gain access to the carefully guarded nucleus of the host cell? In a Perspective, Segura-Totten and Wilson elaborate on new findings (de Noronha et al.) showing that the HIV protein Vpr is crucial for causing transient herniations in the host cell nuclear envelope. These ruptures are sufficient to enable the preintegration complexes of invading virions to enter the nucleus and to integrate with host cell DNA.

The authors are in the Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: klwilson{at}jhmi.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pushing the envelope: microinjection of Minute virus of mice into Xenopus oocytes causes damage to the nuclear envelope.
S. Cohen and N. Pante (2005)
J. Gen. Virol. 86, 3243-3252
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Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages.
S. Iordanskiy, Y. Zhao, P. DiMarzio, I. Agostini, L. Dubrovsky, and M. Bukrinsky (2004)
Blood 104, 1867-1872
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Docking of HIV-1 Vpr to the Nuclear Envelope Is Mediated by the Interaction with the Nucleoporin hCG1.
E. Le Rouzic, A. Mousnier, C. Rustum, F. Stutz, E. Hallberg, C. Dargemont, and S. Benichou (2002)
J. Biol. Chem. 277, 45091-45098
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