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Science 26 October 2001:
Vol. 294. no. 5543, pp. 870 - 875
DOI: 10.1126/science.294.5543.870
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Reports

The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

Qian Huang,1 Dongyu Liu,1 Paul Majewski,1 Leah C. Schulte,1 Joshua M. Korn,2 Richard A. Young,12 Eric S. Lander,123 Nir Hacohen1*

Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.

1 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
2 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
3 Whitehead Institute Center for Genome Research, Cambridge, MA 02139, USA.
*   To whom correspondence should be addressed. E-mail: hacohen{at}wi.mit.edu

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J. Immunol. 172, 2885-2893
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A Type I IFN-Dependent Pathway Induced by Schistosoma mansoni Eggs in Mouse Myeloid Dendritic Cells Generates an Inflammatory Signature.
F. Trottein, N. Pavelka, C. Vizzardelli, V. Angeli, C. S. Zouain, M. Pelizzola, M. Capozzoli, M. Urbano, M. Capron, F. Belardelli, et al.