Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Johnson & Johnson

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 October 2001:
Vol. 294. no. 5542, pp. 567 - 571
DOI: 10.1126/science.1062864
Prev | Table of Contents | Next

Reports

Charge Migration in DNA: Ion-Gated Transport

Robert N. Barnett,1 Charles L. Cleveland,1 Abraham Joy,2 Uzi Landman,1* Gary B. Schuster2*

Electron hole (radical cation) migration in DNA, where the quantum transport of an injected charge is gated in a correlated manner by the thermal motions of the hydrated counterions, is described here. Classical molecular dynamics simulations in conjunction with large-scale first-principles electronic structure calculations reveal that different counterion configurations lead to formation of states characterized by varying spatial distributions and degrees of charge localization. Stochastic dynamic fluctuations between such ionic configurations can induce correlated changes in the spatial distribution of the hole, with concomitant transport along the DNA double helix. Comparative ultraviolet light-induced cleavage experiments on native B DNA oligomers and on ones modified to contain counterion (Na+)-starved bridges between damage-susceptible hole-trapping sites called GG steps show in the latter a reduction in damage at the distal step. This reduction indicates a reduced mobility of the hole across the modified bridge as predicted theoretically.

1 School of Physics,
2 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA.
*   To whom correspondence should be addressed. E-mail: uzi.landman{at}physics.gatech.edu (U.L.); gary.schuster{at}cos.gatech.edu (G.B.S.)

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA damage-site recognition by lysine conjugates.
B. Breiner, J. C. Schlatterer, I. V. Alabugin, S. V. Kovalenko, and N. L. Greenbaum (2007)
PNAS 104, 13016-13021
   Abstract »    Full Text »    PDF »
Electronic energy delocalization and dissipation in single- and double-stranded DNA.
I. Buchvarov, Q. Wang, M. Raytchev, A. Trifonov, and T. Fiebig (2007)
PNAS 104, 4794-4797
   Abstract »    Full Text »    PDF »
X-ray diffraction "fingerprinting" of DNA structure in solution for quantitative evaluation of molecular dynamics simulation.
X. Zuo, G. Cui, K. M. Merz Jr., L. Zhang, F. D. Lewis, and D. M. Tiede (2006)
PNAS 103, 3534-3539
   Abstract »    Full Text »    PDF »
Monitoring the direct and indirect damage of DNA bases and polynucleotides by using time-resolved infrared spectroscopy.
M. K. Kuimova, A. J. Cowan, P. Matousek, A. W. Parker, X. Z. Sun, M. Towrie, and M. W. George (2006)
PNAS 103, 2150-2153
   Abstract »    Full Text »    PDF »
Complementary base-pair-facilitated electron tunneling for electrically pinpointing complementary nucleobases.
T. Ohshiro and Y. Umezawa (2006)
PNAS 103, 10-14
   Abstract »    Full Text »    PDF »
The Nature of Aqueous Tunneling Pathways Between Electron-Transfer Proteins.
J. Lin, I. A. Balabin, and D. N. Beratan (2005)
Science 310, 1311-1313
   Abstract »    Full Text »    PDF »
Effect of condensate formation on long-distance radical cation migration in DNA.
P. Das and G. B. Schuster (2005)
PNAS 102, 14227-14231
   Abstract »    Full Text »    PDF »
Electronic Transport in DNA.
D. Klotsa, R. A. Romer, and M. S. Turner (2005)
Biophys. J. 89, 2187-2198
   Abstract »    Full Text »    PDF »
Chemical Theory and Computation Special Feature: Materials by numbers: Computations as tools of discovery.
U. Landman (2005)
PNAS 102, 6671-6678
   Abstract »    Full Text »    PDF »
From The Cover, Long-Range Electron Transfer Special Feature: Protein-DNA charge transport: Redox activation of a DNA repair protein by guanine radical.
E. Yavin, A. K. Boal, E. D. A. Stemp, E. M. Boon, A. L. Livingston, V. L. O'Shea, S. S. David, and J. K. Barton (2005)
PNAS 102, 3546-3551
   Abstract »    Full Text »    PDF »
From the Cover: Long-range oxidative damage to cytosines in duplex DNA.
F. Shao, M. A. O'Neill, and J. K. Barton (2004)
PNAS 101, 17914-17919
   Abstract »    Full Text »    PDF »
Electron transfer in DNA duplexes containing 2-methyl-1,4-naphthoquinone.
F. Bergeron, D. Houde, D. J. Hunting, and J. R. Wagner (2004)
Nucleic Acids Res. 32, 6154-6163
   Abstract »    Full Text »    PDF »
Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a polarity sensitive probe.
M. M. Somoza, D. Andreatta, C. J. Murphy, R. S. Coleman, and M. A. Berg (2004)
Nucleic Acids Res. 32, 2494-2507
   Abstract »    Full Text »    PDF »
Long-distance radical cation reactions in DNA three-way junctions: inter-arm interaction and migration through the junction.
U. Santhosh and G. B. Schuster (2003)
Nucleic Acids Res. 31, 5692-5699
   Abstract »    Full Text »    PDF »
AC Impedance Spectroscopy of Native DNA and M-DNA.
Y.-T. Long, C.-Z. Li, H.-B. Kraatz, and J. S. Lee (2003)
Biophys. J. 84, 3218-3225
   Abstract »    Full Text »    PDF »
Fluidity of Bound Hydration Layers.
U. Raviv and J. Klein (2002)
Science 297, 1540-1543
   Abstract »    Full Text »    PDF »
Contactless experiments on individual DNA molecules show no evidence for molecular wire behavior.
C. Gomez-Navarro, F. Moreno-Herrero, P. J. de Pablo, J. Colchero, J. Gomez-Herrero, and A. M. Baro (2002)
PNAS 99, 8484-8487
   Abstract »    Full Text »    PDF »
Assembly of Smooth Muscle Myosin by the 38k Protein, a Homologue of a Subunit of Pre-mRNA Splicing Factor-2.
T. Okagaki, A. Nakamura, T. Suzuki, K. Ohmi, and K. Kohama (2000)
J. Cell Biol. 148, 653-664
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)