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Sexual Recombination and the Power of Natural Selection
William R. Rice,*Adam K. Chippindale
Theory predicts that recombination will increase the effectiveness
of natural selection. A Drosophila melanogaster model systemwas developed that increased experimental power with the use ofhigh
experimental replication, explicit tracking of individualgenes, and
high but natural levels of background selection. Eachof 34 independent
experiments traced the fate of a newly arisenmutation located within
genome-wide, synthetic chromosomes thatwere propagated with or without
recombination. An intrinsic advantageto recombination was demonstrated
by the finding that the realizedstrength of selection on new mutations
was markedly increasedwhen recombination was present.
Department of Ecology, Evolution and Marine Biology, University of
California, Santa Barbara, CA 93106-9610, USA.
*
To whom correspondence should be addressed. E-mail:
rice{at}lifesci.ucsb.edu
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[DOI: 10.1126/science.1066241] |Summary »|Full Text »|PDF »
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