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Originally published in Science Express on 20 September 2001
Science 19 October 2001:
Vol. 294. no. 5542, pp. 534 - 536
DOI: 10.1126/science.1066284
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Perspectives

IMMUNOLOGY:
Stress, NK Receptors, and Immune Surveillance

Drew M. Pardoll

It has long been suspected that natural killer (NK) cells are involved in immune surveillance. Now comes new work, described by Pardoll in his Perspective, showing that gd T cells expressing an NK cell receptor called NKG2d are important for detecting precancerous skin epithelial cells in mice (Girardi et al.). Engagement of NKG2d with its ligands Rae-1 or H60 expressed on mouse epidermal cells treated with carcinogens results in activation of gd T cells, which eliminate the precancerous epidermal cells before they become established as tumors.

The author is in the Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. E-mail: dmpardol{at}jhmi.edu

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