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IMMUNOLOGY: Stress, NK Receptors, and Immune Surveillance
Drew M. Pardoll
It has long been suspected that natural killer (NK) cells are involved in immune surveillance. Now comes new work, described by Pardoll in his Perspective, showing that gd T cells expressing an NK cell receptor called NKG2d are important for detecting precancerous skin epithelial cells in mice (Girardi et al.). Engagement of NKG2d with its ligands Rae-1 or H60 expressed on mouse epidermal cells treated with carcinogens results in activation of gd T cells, which eliminate the precancerous epidermal cells before they become established as tumors.
The author is in the Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA. E-mail: dmpardol{at}jhmi.edu
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In Science Magazine
REPORTS
Michael Girardi, David E. Oppenheim, Carrie R. Steele, Julia M. Lewis, Earl Glusac, Renata Filler, Paul Hobby, Brian Sutton, Robert E. Tigelaar, and Adrian C. Hayday (19 October 2001) Science294 (5542), 605.
[DOI: 10.1126/science.1063916] |Abstract »|Full Text »|PDF »|Supplemental Data »
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