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Science 5 October 2001:
Vol. 294. no. 5540, p. 9
DOI: 10.1126/science.294.5540.9h
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This Week in Science

Replication of genomic DNA occurs during the S or synthesis phase of the cell cycle. Although we have detailed knowledge of the dynamics of a few specific replication origins, little is known about how replication occurs for an entire genome. Raghuraman et al. (p. 115) developed a DNA microarray assay that allowed them to analyze the replication of the entire yeast genome. Replication of the ends of each chromosome is highly correlated, and, unlike mammalian cells, there is essentially no correlation between replication and transcription.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)