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BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Jeffrey S. Thompson,1Sarah A. Bixler,1Fang Qian,1Kalpit Vora,1*Martin L. Scott,1Teresa G. Cachero,1Catherine Hession,1Pascal Schneider,2Irene D. Sizing,1Colleen Mullen,1Kathy Strauch,1Mohammad Zafari,1Christopher D. Benjamin,1Jurg Tschopp,2Jeffrey L. Browning,1Christine Ambrose1
B cell homeostasis has been shown to critically depend on
BAFF, the B cell activation factor from the tumor necrosis factor(TNF) family. Although BAFF is already known to bind two
receptors,BCMA and TACI, we have identified a third receptor for BAFF
thatwe have termed BAFF-R. BAFF-R binding appears to be highly
specificfor BAFF, suggesting a unique role for this
ligand-receptor interaction.Consistent with this, the BAFF-R
locus is disrupted in A/WySnJmice, which display a B cell phenotype
qualitatively similar tothat of the BAFF-deficient mice. Thus, BAFF-R
appears to be theprincipal receptor for BAFF-mediated mature B cell
survival.
1 Biogen, 12 Cambridge Center, Cambridge, MA
02142, USA.
2 The Institute of Biochemistry,
University of Lausanne, CH-1066, Epalinges, Switzerland.
*
Present address: Department of Biologics Research, Merck & Co., 126 East Lincoln Avenue, RY 80Y-310, Rahway, NJ 07065, USA.
To whom correspondence should be addressed. E-mail:
christine_ambrose{at}biogen.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Barbara Schiemann, Jennifer L. Gommerman, Kalpit Vora, Teresa G. Cachero, Svetlana Shulga-Morskaya, Max Dobles, Erica Frew, and Martin L. Scott (14 September 2001) Science293 (5537), 2111.
[DOI: 10.1126/science.1061964] |Abstract »|Full Text »|PDF »|Supplemental Data »
PERSPECTIVES
Thomas J. Waldschmidt and Randolph J. Noelle (14 September 2001) Science293 (5537), 2012.
[DOI: 10.1126/science.1065591] |Summary »|Full Text »|PDF »
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B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers.
Tax Deregulation of NF-{kappa}B2 p100 Processing Involves Both {beta}-TrCP-dependent and -independent Mechanisms.
Z. Qu, G. Qing, A. Rabson, and G. Xiao (2004)
J. Biol. Chem.
279, 44563-44572
|Abstract »|Full Text »|PDF »
Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome.
A. J. Novak, D. M. Grote, M. Stenson, S. C. Ziesmer, T. E. Witzig, T. M. Habermann, B. Harder, K. M. Ristow, R. J. Bram, D. F. Jelinek, et al. (2004)
Blood
104, 2247-2253
|Abstract »|Full Text »|PDF »
Rapid Response of Marginal Zone B Cells to Viral Particles.
D. Gatto, C. Ruedl, B. Odermatt, and M. F. Bachmann (2004)
J. Immunol.
173, 4308-4316
|Abstract »|Full Text »|PDF »
Decreased Survival of B Cells of HIV-viremic Patients Mediated by Altered Expression of Receptors of the TNF Superfamily.
S. Moir, A. Malaspina, O. K. Pickeral, E. T. Donoghue, J. Vasquez, N. J. Miller, S. R. Krishnan, M. A. Planta, J. F. Turney, J. S. Justement, et al. (2004)
J. Exp. Med.
200, 587-600
|Abstract »|Full Text »|PDF »
Mechanism of Action of Transmembrane Activator and Calcium Modulator Ligand Interactor-Ig in Murine Systemic Lupus Erythematosus.
M. Ramanujam, X. Wang, W. Huang, L. Schiffer, C. Grimaldi, A. Akkerman, B. Diamond, M. P. Madaio, and A. Davidson (2004)
J. Immunol.
173, 3524-3534
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Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus.
W Stohl, S Metyas, S-M Tan, G S Cheema, B Oamar, V Roschke, Y Wu, K P Baker, and D M Hilbert (2004)
Ann Rheum Dis
63, 1096-1103
|Abstract »|Full Text »|PDF »
TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology.
Y. Sasaki, S. Casola, J. L. Kutok, K. Rajewsky, and M. Schmidt-Supprian (2004)
J. Immunol.
173, 2245-2252
|Abstract »|Full Text »|PDF »
B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation.
S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott (2004)
J. Immunol.
173, 2331-2341
|Abstract »|Full Text »|PDF »
Induction of p100 Processing by NF-{kappa}B-inducing Kinase Involves Docking I{kappa}B Kinase {alpha} (IKK{alpha}) to p100 and IKK{alpha}-mediated Phosphorylation.
B Cell-Activating Factor Belonging to the TNF Family (BAFF)-R Is the Principal BAFF Receptor Facilitating BAFF Costimulation of Circulating T and B Cells.
L. G. Ng, A. P. R. Sutherland, R. Newton, F. Qian, T. G. Cachero, M. L. Scott, J. S. Thompson, J. Wheway, T. Chtanova, J. Groom, et al. (2004)
J. Immunol.
173, 807-817
|Abstract »|Full Text »|PDF »
Engineering an APRIL-specific B Cell Maturation Antigen.
D. R. Patel, H. J. A. Wallweber, J. Yin, S. K. Shriver, S. A. Marsters, N. C. Gordon, M. A. Starovasnik, and R. F. Kelley (2004)
J. Biol. Chem.
279, 16727-16735
|Abstract »|Full Text »|PDF »
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone.
J. Moreaux, E. Legouffe, E. Jourdan, P. Quittet, T. Reme, C. Lugagne, P. Moine, J.-F. Rossi, B. Klein, and K. Tarte (2004)
Blood
103, 3148-3157
|Abstract »|Full Text »|PDF »
Impaired IgA class switching in APRIL-deficient mice.
E. Castigli, S. Scott, F. Dedeoglu, P. Bryce, H. Jabara, A. K. Bhan, E. Mizoguchi, and R. S. Geha (2004)
PNAS
101, 3903-3908
|Abstract »|Full Text »|PDF »
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.
H. Hase, Y. Kanno, M. Kojima, K. Hasegawa, D. Sakurai, H. Kojima, N. Tsuchiya, K. Tokunaga, N. Masawa, M. Azuma, et al. (2004)
Blood
103, 2257-2265
|Abstract »|Full Text »|PDF »
BAFF production by antigen-presenting cells provides T cell co-stimulation.
B. Huard, L. Arlettaz, C. Ambrose, V. Kindler, D. Mauri, E. Roosnek, J. Tschopp, P. Schneider, and L. E. French (2004)
Int. Immunol.
16, 467-475
|Abstract »|Full Text »|PDF »
Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL.
B. He, A. Chadburn, E. Jou, E. J. Schattner, D. M. Knowles, and A. Cerutti (2004)
J. Immunol.
172, 3268-3279
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APRIL-Deficient Mice Have Normal Immune System Development.
E. Varfolomeev, F. Kischkel, F. Martin, D. Seshasayee, H. Wang, D. Lawrence, C. Olsson, L. Tom, S. Erickson, D. French, et al. (2004)
Mol. Cell. Biol.
24, 997-1006
|Abstract »|Full Text »|PDF »
Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function.
L. Gorelik, A. H. Cutler, G. Thill, S. D. Miklasz, D. E. Shea, C. Ambrose, S. A. Bixler, L. Su, M. L. Scott, and S. L. Kalled (2004)
J. Immunol.
172, 762-766
|Abstract »|Full Text »|PDF »
