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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2098 - 2100
DOI: 10.1126/science.1062891
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Reports

Role of Nonimmune IgG Bound to PfEMP1 in Placental Malaria

Kirsten Flick,1 Carin Scholander,1 Qijun Chen,1 Victor Fernandez,1 Bruno Pouvelle,2 Jurg Gysin,2 Mats Wahlgren1*

Infections with Plasmodium falciparum during pregnancy lead to the accumulation of parasitized red blood cells (infected erythrocytes, IEs) in the placenta. IEs of P. falciparum isolates that infect the human placenta were found to bind immunoglobulin G (IgG). A strain of P. falciparum cloned for IgG binding adhered massively to placental syncytiotrophoblasts in a pattern similar to that of natural infections. Adherence was inhibited by IgG-binding proteins, but not by glycosaminoglycans or enzymatic digestion of chondroitin sulfate A or hyaluronic acid. Normal, nonimmune IgG that is bound to a duffy binding-like domain beta  of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) might at the IE surface act as a bridge to neonatal Fc receptors of the placenta.

1 Microbiology and Tumor Biology Center (MTC), Karolinska Institutet and Swedish Institute for Infectious Disease Control, Box 280, S-171 77 Stockholm, Sweden.
2 Unité de Parasitologie Expérimentale, Faculté de Médecine, Université de la Méditerranée (Aix-Marseille II), 13385 Marseille Cedex 5, France.
*   To whom correspondence should be addressed. E-mail: Mats.wahlgren{at}smi.ki.se

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