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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2093 - 2098
DOI: 10.1126/science.1061471
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Reports

Mechanisms of Evolution in Rickettsia conorii and R. prowazekii

Hiroyuki Ogata,1 Stéphane Audic,1 Patricia Renesto-Audiffren,2 Pierre-Edouard Fournier,2 Valérie Barbe,3 Delphine Samson,3 Véronique Roux,2 Pascale Cossart,4 Jean Weissenbach,3 Jean-Michel Claverie,1* Didier Raoult2*

Rickettsia conorii is an obligate intracellular bacterium that causes Mediterranean spotted fever in humans. We determined the 1,268,755-nucleotide complete genome sequence of R. conorii, containing 1374 open reading frames. This genome exhibits 804 of the 834 genes of the previously determined R. prowazekii genome plus 552 supplementary open reading frames and a 10-fold increase in the number of repetitive elements. Despite these differences, the two genomes exhibit a nearly perfect colinearity that allowed the clear identification of different stages of gene alterations with gene remnants and 37 genes split in 105 fragments, of which 59 are transcribed. A 38-kilobase sequence inversion was dated shortly after the divergence of the genus.

1 Information Génétique & Structurale, CNRS-AVENTIS UMR 1889, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.
2 Unité des Rickettsies, Université de la Méditerranée, Faculté de Médecine, CNRS UMR 6020, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France.
3 Genoscope and CNRS UMR 8030, 2 rue Gaston Crémieux, 91000 Evry, France.
4 Institut Pasteur, Unité des Interactions Bactéries-Cellules, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France.
*   To whom correspondence should be addressed. E-mail: Jean-Michel.Claverie{at}igs.cnrs-mrs.fr; Didier.Raoult{at}medecine.univ-mrs.fr

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