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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2084 - 2087
DOI: 10.1126/science.1061935
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Reports

Requirement of Tissue-Selective TBP-Associated Factor TAFII105 in Ovarian Development

Richard N. Freiman,1 Shane R. Albright,12 Shuang Zheng,12 William C. Sha,1 Robert E. Hammer,23 Robert Tjian12*

Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery. Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary. Female mice lacking TAFII105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAFII105 in the granulosa cells of the ovarian follicle. Gene expression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient ovaries. Together, these studies suggest that TAFII105 mediates the transcription of a subset of genes required for proper folliculogenesis in the ovary and establishes TAFII105 as a cell type-specific component of the mammalian transcriptional machinery.

1 Department of Molecular and Cell Biology,
2 Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720-3204, USA.
3 Department of Biochemistry and the Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
*   To whom correspondence should be addressed. E-mail: jmlim{at}uclink4.berkeley.edu

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