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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2018 - 2019
DOI: 10.1126/science.1064982
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Perspectives

MOLECULAR BIOLOGY:
Turning Gene Regulation on Its Head

Richard Losick and Abraham L. Sonenshein

Regulation of the trp operon in E. coli (which contains genes encoding enzymes that make the amino acid tryptophan) has been well worked out. The expression of the trp operon in other bacteria, such as B. subtilis, is less well understood. In a Perspective, Losick and Sonenshein describe new work (Valbuzzi and Yanofsky) that reveals the workings of the B. subtilis trp operon and the unique way in which this organism fine-tunes gene expression.

R. Losick is in the Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. A. L. Sonenshein is in the Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA. E-mail: losick{at}mcb.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)