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Science 24 August 2001:
Vol. 293. no. 5534, pp. 1447 - 1448
DOI: 10.1126/science.1061079
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Perspectives

CELL BIOLOGY:
Caveolae--Not Just Craters in the Cellular Landscape

Jeoung-Sook Shin and Soman N. Abraham

Caveolae are small invaginations in the plasma membrane of mammalian cells that seem to be important for signal transduction and uptake of macromolecules. According to Shin and Abraham in their Perspective, recent work reveals that these cellular craters have been commandeered by pathogens and bacterial toxins, enabling them to gain entry to host cells while avoiding the perils of classic endocytosis and the lysosomal degradation pathway.

The authors are in the Departments of Pathology and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. E-mail: Abrah006{at}mc. duke.edu

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Bacterial Penetration of Bladder Epithelium through Lipid Rafts.
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Viral Fusogenic Membrane Glycoproteins Kill Solid Tumor Cells by Nonapoptotic Mechanisms That Promote Cross Presentation of Tumor Antigens by Dendritic Cells.
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A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains.
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Lipoplex-mediated Transfection of Mammalian Cells Occurs through the Cholesterol-dependent Clathrin-mediated Pathway of Endocytosis.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)