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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1083 - 1085
DOI: 10.1126/science.1063073
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Epigenetic Aspects of X-Chromosome Dosage Compensation

Yongkyu Park, Mitzi I. Kuroda

The X chromosomes of mammals and fruit flies exhibit unusual properties that have evolved to deal with the different dosages of X-linked genes in males (XY) and females (XX). The X chromosome dosage-compensation mechanisms discovered in these species are evolutionarily unrelated, but exhibit surprising parallels in their regulatory strategies. These features include the importance of noncoding RNAs, and epigenetic spreading of chromatin-modifying activities.

Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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