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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1034 - 1036
DOI: 10.1126/science.293.5532.1034
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News Focus

Building a Small-Animal Model for AIDS, Block by Block

Jon Cohen

A few labs have been plugging away for years to develop cheap, malleable animal models for AIDS, say, a rat or a mouse, to help speed up research, but HIV stubbornly refuses to infect animals other than humans and chimpanzees. Recent findings have brought the goal closer, but some AIDS researchers remain skeptical that it can be done. Some even argue that the whole effort is an exercise in futility, because by the time researchers engineer both the animal and the virus to produce a model, it will no longer bear enough resemblance to the actual disease.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Replacement of Murine Leukemia Virus Readthrough Mechanism by Human Immunodeficiency Virus Frameshift Allows Synthesis of Viral Proteins and Virus Replication.
M.-N. Brunelle, L. Brakier-Gingras, and G. Lemay (2003)
J. Virol. 77, 3345-3350
   Abstract »    Full Text »    PDF »
Induction of HIV-1-Specific Immunity After Vaccination with Apoptotic HIV-1/Murine Leukemia Virus-Infected Cells.
A.-L. Spetz, A. S. Sorensen, L. Walther-Jallow, B. Wahren, J. Andersson, L. Holmgren, and J. Hinkula (2002)
J. Immunol. 169, 5771-5779
   Abstract »    Full Text »    PDF »
Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells.
B. K. Chen, I. Rousso, S. Shim, and P. S. Kim (2001)
PNAS
   Abstract »    Full Text »    PDF »
Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells.
B. K. Chen, I. Rousso, S. Shim, and P. S. Kim (2001)
PNAS 98, 15239-15244
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)