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Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Hervé Tettelin,1Karen E. Nelson,1Ian T. Paulsen,12Jonathan A. Eisen,12Timothy D. Read,1Scott Peterson,13John Heidelberg,1Robert T. DeBoy,1Daniel H. Haft,1Robert J. Dodson,1A. Scott Durkin,1Michelle Gwinn,1James F. Kolonay,1William C. Nelson,1Jeremy D. Peterson,1Lowell A. Umayam,1Owen White,1Steven L. Salzberg,14Matthew R. Lewis,1Diana Radune,1Erik Holtzapple,1Hoda Khouri,1Alex M. Wolf,1Terry R. Utterback,1Cheryl L. Hansen,1Lisa A. McDonald,1Tamara V. Feldblyum,1Samuel Angiuoli,1Tanja Dickinson,1Erin K. Hickey,1Ingeborg E. Holt,1Brendan J. Loftus,1Fan Yang,1Hamilton O. Smith,1*J. Craig Venter,1*Brian A. Dougherty,5Donald A. Morrison,6Susan K. Hollingshead,7Claire M. Fraser13
The 2,160,837-base pair genome sequence of an isolate
of Streptococcus pneumoniae, a Gram-positive pathogen that
causes pneumonia,bacteremia, meningitis, and otitis media, contains
2236 predictedcoding regions; of these, 1440 (64%) were assigned a
biologicalrole. Approximately 5% of the genome is composed of
insertionsequences that may contribute to genome rearrangements
throughuptake of foreign DNA. Extracellular enzyme systems for the
metabolismof polysaccharides and hexosamines provide a substantial
sourceof carbon and nitrogen for S. pneumoniae and also
damage hosttissues and facilitate colonization. A motif identified
withinthe signal peptide of proteins is potentially involved in
targetingthese proteins to the cell surface of low-guanine/cytosine
(GC)Gram-positive species. Several surface-exposed proteins that mayserve as potential vaccine candidates were identified. Comparativegenome hybridization with DNA arrays revealed strain differencesin
S. pneumoniae that could contribute to differences in
virulenceand antigenicity.
1 The Institute for Genomic Research
(TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.
2 Johns Hopkins University, Charles and 34th
Streets, Baltimore, MD 21218, USA.
3 George
Washington University Medical Center, 2300 Eye Street, NW, Washington,
DC 20037, USA.
4 Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
5 Bristol-Myers Squibb PRI, 5 Research Parkway,
Wallingford, CT 06492, USA.
6 University of Illinois
at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA.
7 University of Alabama at Birmingham, 845 19th
Street South, Birmingham, AL 35294, USA.
*
Present address: Celera Genomics, 45 West Gude Drive, Rockville,
MD 20850, USA.
To whom correspondence should be addressed. E-mail:
cmfraser{at}tigr.org
The editors suggest the following Related Resources on Science sites:
In Science Magazine
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Dan Ferber (20 July 2001) Science293 (5529), 410.
[DOI: 10.1126/science.293.5529.410] |Summary »|Full Text »
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J. Immunol.
177, 6182-6191
|Abstract »|Full Text »|PDF »
Immunization with Polyamine Transport Protein PotD Protects Mice against Systemic Infection with Streptococcus pneumoniae..
Comparative Genomic Evidence for a Close Relationship between the Dimorphic Prosthecate Bacteria Hyphomonas neptunium and Caulobacter crescentus..
J. H. Badger, T. R. Hoover, Y. V. Brun, R. M. Weiner, M. T. Laub, G. Alexandre, J. Mrazek, Q. Ren, I. T. Paulsen, K. E. Nelson, et al. (2006)
J. Bacteriol.
188, 6841-6850
|Abstract »|Full Text »|PDF »
Regulation of Glutamine and Glutamate Metabolism by GlnR and GlnA in Streptococcus pneumoniae.
T. G. Kloosterman, W. T. Hendriksen, J. J. E. Bijlsma, H. J. Bootsma, S. A. F. T. van Hijum, J. Kok, P. W. M. Hermans, and O. P. Kuipers (2006)
J. Biol. Chem.
281, 25097-25109
|Abstract »|Full Text »|PDF »
Lysogeny of Streptococcus pneumoniae with MM1 Phage: Improved Adherence and Other Phenotypic Changes..
Maltodextrin utilization plays a key role in the ability of group a streptococcus to colonize the oropharynx..
S. A. Shelburne III, P. Sumby, I. Sitkiewicz, N. Okorafor, C. Granville, P. Patel, J. Voyich, R. Hull, F. R. DeLeo, and J. M. Musser (2006)
Infect. Immun.
74, 4605-4614
|Abstract »|Full Text »|PDF »
Identification of a Candidate Streptococcus pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease..
C. Obert, J. Sublett, D. Kaushal, E. Hinojosa, T. Barton, E. I. Tuomanen, and C. J. Orihuela (2006)
Infect. Immun.
74, 4766-4777
|Abstract »|Full Text »|PDF »
A Functional dlt Operon, Encoding Proteins Required for Incorporation of D-Alanine in Teichoic Acids in Gram-Positive Bacteria, Confers Resistance to Cationic Antimicrobial Peptides in Streptococcus pneumoniae..
M. Kovacs, A. Halfmann, I. Fedtke, M. Heintz, A. Peschel, W. Vollmer, R. Hakenbeck, and R. Bruckner (2006)
J. Bacteriol.
188, 5797-5805
|Abstract »|Full Text »|PDF »
Cell Wall-Mediated Neuronal Damage in Early Sepsis.
C. J. Orihuela, S. Fillon, S. H. Smith-Sielicki, K. C. El Kasmi, G. Gao, K. Soulis, A. Patil, P. J. Murray, and E. I. Tuomanen (2006)
Infect. Immun.
74, 3783-3789
|Abstract »|Full Text »|PDF »
Acyl Carrier Protein Synthases from Gram-Negative, Gram-Positive, and Atypical Bacterial Species: Biochemical and Structural Properties and Physiological Implications.
K. A. McAllister, R. B. Peery, and G. Zhao (2006)
J. Bacteriol.
188, 4737-4748
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Interference between Streptococcus pneumoniae and Staphylococcus aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus pneumoniae.
G. Regev-Yochay, K. Trzcinski, C. M. Thompson, R. Malley, and M. Lipsitch (2006)
J. Bacteriol.
188, 4996-5001
|Abstract »|Full Text »|PDF »
Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysans.
N. Takenouchi-Ohkubo, L. M. Mortensen, K. R. Drasbek, M. Kilian, and K. Poulsen (2006)
Microbiology
152, 2171-2180
|Abstract »|Full Text »|PDF »
BAGEL: a web-based bacteriocin genome mining tool..
A. de Jong, S. A. F. T. van Hijum, J. J. E. Bijlsma, J. Kok, and O. P. Kuipers (2006)
Nucleic Acids Res.
34, W273-W279
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Streptococcus pneumoniae Recruits Complement Factor H through the Amino Terminus of CbpA.
Competitive metagenomic DNA hybridization identifies host-specific microbial genetic markers in cow fecal samples..
O. C. Shanks, J. W. Santo Domingo, R. Lamendella, C. A. Kelty, and J. E. Graham (2006)
Appl. Envir. Microbiol.
72, 4054-4060
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Genomic Diversity between Strains of the Same Serotype and Multilocus Sequence Type among Pneumococcal Clinical Isolates..
N. A. Silva, J. McCluskey, J. M. C. Jefferies, J. Hinds, A. Smith, S. C. Clarke, T. J. Mitchell, and G. K. Paterson (2006)
Infect. Immun.
74, 3513-3518
|Abstract »|Full Text »|PDF »
Effect of subinhibitory concentrations of antibiotics on mutation frequency in Streptococcus pneumoniae.
S. K. Henderson-Begg, D. M. Livermore, and L. M. C. Hall (2006)
J. Antimicrob. Chemother.
57, 849-854
|Abstract »|Full Text »|PDF »
Phenotypic Characterization of Streptococcus pneumoniae Biofilm Development..
M. Allegrucci, F. Z. Hu, K. Shen, J. Hayes, G. D. Ehrlich, J. C. Post, and K. Sauer (2006)
J. Bacteriol.
188, 2325-2335
|Abstract »|Full Text »|PDF »
