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Science 13 July 2001:
Vol. 293. no. 5528, pp. 245 - 248
DOI: 10.1126/science.1062416
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T Cell Death and Memory

Jonathan Sprent,* David F. Toughdagger

In typical immune responses, contact with antigen causes naïve T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated--thereby preserving the primary T cell repertoire--but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.

Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
*   To whom correspondence should be addressed: jsprent{at}scripps.edu

dagger    Present address: The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire RG20 7NN, UK.

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