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SIGNAL TRANSDUCTION: Bringing Channels Closer to the Action!
Stéphane A. Laporte, Robert H. Oakley, Marc G. Caron
How does a cell expressing many different G protein-coupled receptors (GPCRs) know which signaling pathway and target proteins to activate when a GPCR binds to its ligand? As Laporte et al. explain in their Perspective, new findings (Davare et al.) suggest that the cell assembles a multiprotein complex in the plasma membrane that contains the GPCR, its signaling proteins, and the final target effector protein, thus ensuring that the GPCR activates only the correct signaling pathway, and target effector protein.
The authors are at the Howard Hughes Medical Institute Laboratories, Departments of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA. E-mail: caron002{at}mc.duke.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Monika A. Davare, Vladimir Avdonin, Duane D. Hall, Erik M. Peden, Alain Burette, Richard J. Weinberg, Mary C. Horne, Toshinori Hoshi, and Johannes W. Hell (6 July 2001) Science293 (5527), 98.
[DOI: 10.1126/science.293.5527.98] |Abstract »|Full Text »|PDF »
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Circ. Res.
95, 67-75
|Abstract »|Full Text »|PDF »
