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Science 6 July 2001:
Vol. 293. no. 5527, pp. 60 - 62
DOI: 10.1126/science.1062237
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Perspectives

DEVELOPMENT:
The Message Is in the Translation

Joel D. Richter and William E. Theurkauf

It has been well established that cells control the activities of proteins by regulating their degradation. Now it seems cells also control protein activity by regulating when and where mRNAs encoding cellular proteins are translated. In their Perspective, Richter and Theurkauf examine how regulation of the translation of cyclin B and hunchback mRNAs controls cell proliferation and pattern formation in the developing fly embryo.

The authors are in the Department of Molecular Genetics and Microbiology and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. E-mail: joel.richter{at}umassmed.edu, william.theurkauf@umassmed.edu

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