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Science 22 June 2001:
Vol. 292. no. 5525, pp. 2285 - 2289
DOI: 10.1126/science.1062013
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Review

Common and Contrasting Themes of Plant and Animal Diseases

Brian J. Staskawicz,1* Mary Beth Mudgett,1 Jeffrey L. Dangl,2 Jorge E. Galan3

Recent studies in bacterial pathogenesis reveal common and contrasting mechanisms of pathogen virulence and host resistance in plant and animal diseases. This review presents recent developments in the study of plant and animal pathogenesis, with respect to bacterial colonization and the delivery of effector proteins to the host. Furthermore, host defense responses in both plants and animals are discussed in relation to mechanisms of pathogen recognition and defense signaling. Future studies will greatly add to our understanding of the molecular events defining host-pathogen interactions.

1 Department of Plant and Microbial Biology, University of California at Berkeley, Berkeley, CA 94720, USA.
2 Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
3 Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
*   To whom correspondence should addressed. E-mail: stask{at}nature.berkeley.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)