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Science 22 June 2001:
Vol. 292. no. 5525, pp. 2266 - 2267
DOI: 10.1126/science.1063024
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Perspectives

NEUROBIOLOGY:
Total Recall--the Memory of Addiction

Eric J. Nestler

How does cocaine induce the long-lasting changes in neural circuitry that result in addictive behavior? As Nestler explains in his Perspective, the formation of memories through long-term potentiation (LTP) in the hippocampus may provide some clues. Discussing a paper from Malenka and colleagues published elsewhere, Nestler compares the increase in glutamatergic transmission accompanying LTP in the hippocampus with that induced in VTA dopamine neurons by cocaine.

The author is in the Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390--9070, USA. E-mail: eric.nestler{at}utsouthwestern.edu

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