Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Why does the p53 tumor suppressor protein need two nuclear export signals? In their Perspective, Gottifredi and Prives set out to answer this question. They discuss new findings (Zhang and Xiong) suggesting that, in the unstressed cell, the two nuclear export signals may act together to promote the movement of p53 from the nucleus into the cytoplasm, where it is degraded.
The authors are in the Department of Biological Sciences, Columbia University, New York, NY 10027, USA. E-mail: clp3{at}columbia.edu
Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1..
Y. Zhao, S. Lu, L. Wu, G. Chai, H. Wang, Y. Chen, J. Sun, Y. Yu, W. Zhou, Q. Zheng, et al. (2006)
Mol. Cell. Biol.
26, 2782-2790
|Abstract »|Full Text »|PDF »
Role of the Histone Acetyl Transferase Tip60 in the p53 Pathway.
G. Legube, L. K. Linares, S. Tyteca, C. Caron, M. Scheffner, M. Chevillard-Briet, and D. Trouche (2004)
J. Biol. Chem.
279, 44825-44833
|Abstract »|Full Text »|PDF »
Mitogen-Activated Protein Kinase Regulates Nuclear Association of Human Progesterone Receptors.
M. Qiu, A. Olsen, E. Faivre, K. B. Horwitz, and C. A. Lange (2003)
Mol. Endocrinol.
17, 628-642
|Abstract »|Full Text »|PDF »
