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STRUCTURAL BIOLOGY: A Marvellous Machine for Making Messages
Aaron Klug
The wonderful x-ray structures of RNA polymerase published in the past 3 years have revealed a wealth of information about how genes are transcribed. In an eloquent Perspective, Klug describes the latest tour de force from Kornberg's laboratory: the crystal structure of yeast RNA polymerase II in action.
The author is at the MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
RESEARCH ARTICLES
Patrick Cramer, David A. Bushnell, and Roger D. Kornberg (8 June 2001) Science292 (5523), 1863.
[DOI: 10.1126/science.1059493] |Abstract »|Full Text »|PDF »
RESEARCH ARTICLES
Averell L. Gnatt, Patrick Cramer, Jianhua Fu, David A. Bushnell, and Roger D. Kornberg (8 June 2001) Science292 (5523), 1876.
[DOI: 10.1126/science.1059495] |Abstract »|Full Text »|PDF »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphorylation of the C-terminal Domain of RNA Polymerase II Plays Central Roles in the Integrated Events of Eucaryotic Gene Expression.
A New Class of Transcription Initiation Factors, Intermediate between TATA Box-binding Proteins (TBPs) and TBP-like Factors (TLFs), Is Present in the Marine Unicellular Organism, the Dinoflagellate Crypthecodinium cohnii.
D. Guillebault, S. Sasorith, E. Derelle, J.-M. Wurtz, J.-C. Lozano, S. Bingham, L. Tora, and H. Moreau (2002)
J. Biol. Chem.
277, 40881-40886
|Abstract »|Full Text »|PDF »
Structural basis of transcription: alpha -Amanitin-RNA polymerase II cocrystal at 2.8 A resolution.
