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Science 25 May 2001:
Vol. 292. no. 5521, p. 1445
DOI: 10.1126/science.292.5521.1445n
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This Week in Science

Many neurodegenerative disorders are characterized by the prevalence of protein aggregates in the brain. These aggregates are often composed of proteins that have been modified by the addition of ubiquitin--a marker that should lead to degradation of the offending protein by a cytosolic proteolytic complex known as the proteasome--but are the aggregates a cause or a consequence of the disease process· Bence et al. (p. 1552; see the news story by Helmuth) now show that protein aggregation per se appears to inhibit the proteasomal protein degradation system.




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