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Science 18 May 2001:
Vol. 292. no. 5520, pp. 1313 - 1314
DOI: 10.1126/science.1061114
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Perspectives

CELL BIOLOGY:
A TIP About Rabs

Nava Segev

Are Rab guanosine triphosphatases involved in the formation as well as the targeting of transport vesicles containing protein cargo? In this Perspective, Segev explains new findings showing that this is indeed the case. Not only does Rab9 recruit its effector TIP47 to budding vesicle membranes, it also enhances interactions between TIP47 and the mannose-6-phosphate cargo receptor. A complex among Rab9, TIP47, and mannose-6-phosphate receptors is probably important for vesicle budding.

The author is in the Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, IL 60607, USA. E-mail: nava{at}uic.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ypt31/32 GTPases and Their Novel F-Box Effector Protein Rcy1 Regulate Protein Recycling.
S. H. Chen, S. Chen, A. A. Tokarev, F. Liu, G. Jedd, and N. Segev (2005)
Mol. Biol. Cell 16, 178-192
   Abstract »    Full Text »    PDF »
Rab8B GTPase and Junction Dynamics in the Testis.
A. S. N. Lau and D. D. Mruk (2003)
Endocrinology 144, 1549-1563
   Abstract »    Full Text »    PDF »
Ypt/Rab GTPases: Regulators of Protein Trafficking.
N. Segev (2001)
Sci. STKE 2001, re11
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)