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Science 18 May 2001:
Vol. 292. no. 5520, p. 1257
DOI: 10.1126/science.292.5520.1257n
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Although some abnormalities of the digestive tract result in morphological disruptions, abnormalities of digestive physiology, which may have greater relevance to studies of normal human physiology, may be more difficult to uncover in the small animals that are amenable to study. Using zebrafish and fluorescently tagged phospholipids, Farber et al. (p. 1385) have analyzed the digestive processing of lipids and identified a new mutation, fat free, that is defective in phospholipid and cholesterol processing. These fluorescently tagged phospholipids promise to be useful for analyzing other aspects of digestion and for screening compounds that may affect digestive physiology.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)