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Science 11 May 2001:
Vol. 292. no. 5519, pp. 1099 - 1102
DOI: 10.1126/science.1059410
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The Ecology of Genetically Diverse Infections

Andrew F. Read,1* Louise H. Taylor2

Microparasite infections often consist of genetically distinct clonal lineages. Ecological interactions between these lineages within hosts can influence disease severity, epidemiology, and evolution. Many medical and veterinary interventions have an impact on genetic diversity within infections, but there is little understanding of the long-term consequences of such interventions for public and animal health. Indeed, much of the theory in this area is based on assumptions contradicted by the available data.

1 Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.
2 Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK.
*   To whom correspondence should be addressed. E-mail: a.read{at}ed.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)