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Science 27 April 2001:
Vol. 292. no. 5517, p. 597
DOI: 10.1126/science.292.5517.597o
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This Week in Science

The ligand Slit and its corresponding receptor Robo are notorious for providing guidance signals to axons finding their initial pathways during early Drosophila development. Kramer et al. (p. 737) now show that the Slit/Robo combination is even more versatile than previously thought. Muscle cells also migrate during the early stages of muscle organization under the direction of the Slit/Robo team. The response switches from repulsive to attractive; initially repelled by Slit at the midline, muscle cells are later attracted by Slit at specific attachment sites.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)