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Science 13 April 2001:
Vol. 292. no. 5515, pp. 236 - 237
DOI: 10.1126/science.1060028
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Perspectives

NEUROSCIENCE:
A Kinase to Dampen the Effects of Cocaine?

Amitabh Gupta and Li-Huei Tsai

Chronic exposure to cocaine results in long-term changes in the central nervous system (CNS). In their Perspective, Gupta and Tsai discuss new results, reported elsewhere, that elucidate the signaling pathways that promote and dampen down the effects of chronic cocaine on the CNS. They explain the part played by a cyclin-dependent kinase (Cdk5), which is switched on by the DFosB transcription factor and regulates PKA-dependent signaling pathways, resulting in a dampening of the effects of chronic cocaine.

The authors are in the Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA. E-mail: li-huei_tsai{at}hms.harvard.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)