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Science 23 March 2001:
Vol. 291. no. 5512, pp. 2417 - 2419
DOI: 10.1126/science.1058165
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Reports

Memory Extinction, Learning Anew, and Learning the New: Dissociations in the Molecular Machinery of Learning in Cortex

Diego E. Berman, Yadin Dudai*

The rat insular cortex (IC) subserves the memory of conditioned taste aversion (CTA), in which a taste is associated with malaise. When the conditioned taste is unfamiliar, formation of long-term CTA memory depends on muscarinic and beta -adrenergic receptors, mitogen-activated protein kinase (MAPK), and protein synthesis. We show that extinction of CTA memory is also dependent on protein synthesis and beta -adrenergic receptors in the IC, but independent of muscarinic receptors and MAPK. This resembles the molecular signature of the formation of long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with learning, but the mechanisms of learning anew differ from those of learning the new.

Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.
*   To whom correspondence should be addressed at yadin.dudai{at}weizmann.ac.il

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