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Science 9 March 2001:
Vol. 291. no. 5510, pp. 1916 - 1917
DOI: 10.1126/science.1059682
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Perspectives

MOLECULAR BIOLOGY:
RNP Remodeling With DExH/D Boxes

Cindy L. Will and Reinhard Lührmann

The DExH/D proteins are known to have RNA helicase activity, that is, they bind to and unwind double-stranded RNA. As Will and Lührmann explain in their Perspective, these enzymes can also behave as RNPases, disrupting the interactions between RNA and proteins in ribonucleoprotein complexes such as the spliceosome.

The authors are in the Cellular Biochemistry Department, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. E-mail: cwill1{at}gwdg.de; reinhard.luehrmann{at}mpi-bpc.mpg.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Dynamic Scaffold of Pre-snoRNP Factors Facilitates Human Box C/D snoRNP Assembly.
K. S. McKeegan, C. M. Debieux, S. Boulon, E. Bertrand, and N. J. Watkins (2007)
Mol. Cell. Biol. 27, 6782-6793
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The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.
S. Liu, R. Rauhut, H.-P. Vornlocher, and R. Luhrmann (2006)
RNA 12, 1418-1430
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ATPase/Helicase Activities of p68 RNA Helicase Are Required for Pre-mRNA Splicing but Not for Assembly of the Spliceosome.
C. Lin, L. Yang, J. J. Yang, Y. Huang, and Z.-R. Liu (2005)
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Crystal structure of the human ATP-dependent splicing and export factor UAP56.
H. Shi, O. Cordin, C. M. Minder, P. Linder, and R.-M. Xu (2004)
PNAS 101, 17628-17633
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Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding.
M. E. Fairman, P. A. Maroney, W. Wang, H. A. Bowers, P. Gollnick, T. W. Nilsen, and E. Jankowsky (2004)
Science 304, 730-734
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Ded1p, a conserved DExD/H-box translation factor, can promote yeast L-A virus negative-strand RNA synthesis in vitro.
J.-L. Chong, R.-Y. Chuang, L. Tung, and T.-H. Chang (2004)
Nucleic Acids Res. 32, 2031-2038
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Splicing enhances translation in mammalian cells: an additional function of the exon junction complex.
A. Nott, H. Le Hir, and M. J. Moore (2004)
Genes & Dev. 18, 210-222
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Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72.
A. Honig, D. Auboeuf, M. M. Parker, B. W. O'Malley, and S. M. Berget (2002)
Mol. Cell. Biol. 22, 5698-5707
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p68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5' Splice Site Duplex.
Z.-R. Liu (2002)
Mol. Cell. Biol. 22, 5443-5450
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Probing Interactions between the U2 Small Nuclear Ribonucleoprotein and the DEAD-box Protein, Prp5.
B. K. Abu Dayyeh, T. K. Quan, M. Castro, and S. W. Ruby (2002)
J. Biol. Chem. 277, 20221-20233
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