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Science 2 March 2001:
Vol. 291. no. 5509, pp. 1738 - 1742
DOI: 10.1126/science.291.5509.1738
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Review
Genealogical and Evolutionary Inference with the Human Y Chromosome
Michael P. H. Stumpf,1
David B. Goldstein2*
Population genetics has emerged as a powerful tool for
unraveling human history. In addition to the study of mitochondrial and
autosomal DNA, attention has recently focused on Y-chromosome variation. Ambiguities and inaccuracies in data analysis, however, pose
an important obstacle to further development of the field. Here we
review the methods available for genealogical inference using
Y-chromosome data. Approaches can be divided into those that do and
those that do not use an explicit population model in genealogical
inference. We describe the strengths and weaknesses of these
model-based and model-free approaches, as well as difficulties associated with the mutation process that affect both methods. In the
case of genealogical inference using microsatellite loci, we use
coalescent simulations to show that relatively simple generalizations of the mutation process can greatly increase the accuracy of
genealogical inference. Because model-free and model-based approaches
have different biases and limitations, we conclude that there is
considerable benefit in the continued use of both types of
approaches.
1 Department of Zoology, University of Oxford,
Oxford OX1 3PS, UK.
2 Department of Biology,
University College London, Wolfson House, 4 Stephenson Way, London NW1
2HE, UK.
*
To whom correspondence should be addressed. E-mail:
d.goldstein{at}ucl.ac.uk
Read the Full Text
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