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Science 2 March 2001:
Vol. 291. no. 5509, pp. 1713 - 1714
DOI: 10.1126/science.1059665
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Perspectives

DEVELOPMENT:
The Art of Making a Joint

François Spitz and Denis Duboule

Formation of the skeleton's long bones during development of the vertebrate embryo is well established. However, introduction of articulations or joints in between the bones has not been well characterized. In a Perspective, Spitz and Duboule explain the part played by Wnt14 (a member of the Wnt family of signaling molecules) in specifying areas called interzones within the primordial bone tissue that will eventually form the joints.

The authors are in the Department of Zoology and Animal Biology, University of Geneva, Sciences III, 1211 Geneve 4, Switzerland. E-mail: denis.duboule{at}zoo.unige

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The homeobox transcription factor Barx2 regulates chondrogenesis during limb development.
R. Meech, D. B. Edelman, F. S. Jones, and H. P. Makarenkova (2005)
Development 132, 2135-2146
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Selective Activation of the MEK-ERK Pathway Is Regulated by Mechanical Stimuli in Forming Joints and Promotes Pericellular Matrix Formation.
E. R. Bastow, K. J. Lamb, J. C. Lewthwaite, A. C. Osborne, E. Kavanagh, C. P. D. Wheeler-Jones, and A. A. Pitsillides (2005)
J. Biol. Chem. 280, 11749-11758
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